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Licensed Unlicensed Requires Authentication Published by De Gruyter February 23, 2012

The predictive value of immature granulocyte count and immature myeloid information in the diagnosis of neonatal sepsis

  • Christina Cimenti EMAIL logo , Wolfgang Erwa , Kurt R. Herkner , David C. Kasper , Wilhelm Müller and Bernhard Resch


Background: To determine the predictive value of the immature granulocyte count and the immature myeloid information in neonatal early onset sepsis we examined 133 blood samples of patients admitted to our neonatal intensive care unit.

Methods: Measurements were performed using the Sysmex XE-2100, an automated hematological analyzer. Patients were divided into two groups: 1) symptomatic neonates with diagnosis of early onset sepsis; and 2) controls including asymptomatic neonates who were admitted because of prematurity, low birth weight, or delayed postnatal transition.

Results: The number of immature granulocytes and the immature myeloid information were significantly elevated in neonates with early onset sepsis compared to controls (median 280/μL vs. 50/μL, p=0.049 and 639/μL vs. 89/μL, p<0.0001, respectively).

Conclusions: Automated determinations of immature granulocytes and immature myeloid information seem to be useful adjunctive methods in the diagnosis of neonatal early onset sepsis.

Corresponding author: Dr. Christina Cimenti, Department of Pediatrics, Medical University of Graz, Auenbruggerplatz 30, 8036 Graz, Austria Phone: +43 316 38512605, Fax: +43 316 38512619

Received: 2011-9-13
Accepted: 2012-2-6
Published Online: 2012-02-23
Published in Print: 2012-08-01

©2012 by Walter de Gruyter Berlin Boston

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