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Licensed Unlicensed Requires Authentication Published by De Gruyter February 21, 2014

Measurement error in estimated average glucose: a novel approach

  • Joanne E. Given EMAIL logo , Brendan P. Bunting , Vivien E. Coates and Maurice J. O’Kane

Corresponding author: Joanne E. Given, G229, Institute of Nursing Research, University of Ulster, Coleraine Campus, Cromore Road, Co. Londonderry, BT52 1SA, UK, Phone: +353 2870124094, Fax: +353 2870124951, E-mail:


We would like to thank the participants of the ESMON study.

Conflict of interest statement

Authors’ conflict of interest disclosure: The authors stated that there are no conflicts of interest regarding the publication of this article. Research funding played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

Research funding: The efficacy of self-monitoring of blood glucose in patients with newly diagnosed Type 2 diabetes (ESMON study) was funded by the Northern Ireland Department of Health Research and Development Office. This work will constitute part of a PhD for JEG which has been funded by the Department for Employment and Learning for Northern Ireland.

Competing interests: MJO’K has received research funding from Nova Biomedical, a manufacturer of blood glucose meters.

Employment or leadership: None declared.

Honorarium: None declared.

Ethical approval: Ethical approval for the ESMON study was obtained from the University of Ulster ethics committee (Reference number: 01/29).

Guarantor: MJO’K

Contributorship: MJO’K, BPB and VEC were involved in protocol development, gaining ethical approval, patient recruitment and data analysis for the ESMON study, of which this is a secondary data analysis. MJO’K, BPB and JEG conceived the study. JEG researched the literature, input data and wrote the first draft of this article. JEG and BPB performed the statistical analysis. All authors reviewed and edited the manuscript and approved the final version of the manuscript.


1. Nathan DM, Kuenen JC, Borg R, Zheng H, Schoenfeld D, Heine RJ. Translating the A1c Assay into estimated average glucose values. Diabetes Care 2008;31:1473–8.10.2337/dc08-0545Search in Google Scholar PubMed PubMed Central

2. Rohlfing CL, England JD, Wiedmeyer H, Tennill A, Little RR, Goldsetin DE. Defining the relationship between plasma glucose and HbA1c: analysis of glucose profiles and HbA1c in the Diabetes Control and Complications Trial. Diabetes Care 2002;25:275–8.10.2337/diacare.25.2.275Search in Google Scholar PubMed

3. Bland JM, Altman DG. Statistics notes: measurement error and correlation coefficients. Br Med J 1996;313:41–2.10.1136/bmj.313.7048.41Search in Google Scholar PubMed PubMed Central

4. Sacks DB. Correlation between haemoglobin A1c (HbA1c) and average blood glucose: can HbA1c be reported as estimated blood glucose concentration? J Diabetes Sci Technol 2007;1:801–3.10.1177/193229680700100602Search in Google Scholar PubMed PubMed Central

5. Rabe-Hesketh S, Skrondal A. Classical latent variable models for medical research. Stat Methods Med Res 2008;17:5–32.10.1177/0962280207081236Search in Google Scholar PubMed

6. Bollen K. Structural equations with latent variables. New York: John Wiley & Sons Inc., 1989.10.1002/9781118619179Search in Google Scholar

7. Brown TA. Confirmatory factor analysis for applied research. London: The Guilford Press, 2006.Search in Google Scholar

8. O’Kane MJ, Bunting B, Copeland M, Coates VE. Efficacy of self monitoring of blood glucose in patients with newly diagnosed type 2 diabetes (ESMON study): randomised controlled trial. Br Med J 2008;336:1174–7.10.1136/bmj.39534.571644.BESearch in Google Scholar PubMed PubMed Central

9. Clarke R, Shipley M, Lewington S, Youngman L, Collins R, Marmot M, et al. Underestimation of risk associations due to regression dilution in long-term follow-up of prospective studies. Am J Epidemiol 1999;150:341–53.10.1093/oxfordjournals.aje.a010013Search in Google Scholar PubMed

10. Bunting B, Saris W, McCormack J. A secondorder factor analysis of the reliability and validity of the 11+ examination in Northern Ireland. Econ Social Rev 1987;18:137–47.Search in Google Scholar

Received: 2013-12-27
Accepted: 2014-1-28
Published Online: 2014-2-21
Published in Print: 2014-7-1

©2014 by Walter de Gruyter Berlin/Boston

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