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Licensed Unlicensed Requires Authentication Published by De Gruyter November 17, 2015

Platelet volume is associated with the Framingham risk score for cardiovascular disease in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

  • Chams B. Maluf , Sandhi M. Barreto , Rodrigo C.P. dos Reis and Pedro G. Vidigal EMAIL logo



Platelet volume indices (PVI), an easy and inexpensive surrogate measure of platelet function, have been associated with cardiovascular diseases (CVD) and their risk factors. However, results are conflicting because of the lack of standardized procedures. The purpose of this study is to investigate the relationship of PVI with the Framingham risk score (FRS).


Baseline data (2008–2010) of 3115 participants enrolled in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) were used. PVI measurements were strictly controlled. The cohort was distributed according to risk factors and the general FRS was estimated. Multiple linear regression analysis was used to estimate the association between PVI and FRS.


Mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR) independently correlated (p≤0.01) with FRS after adjustment for confounding variables. One unit increase in MPV, PDW, or P-LCR increased the FRS by 0.59%, 0.40%, and 0.08%, respectively. Diabetics had higher (p≤0.004) MPV, PDW, and P-LCR, and hypertensive individuals had higher (p≤0.045) PDW and P-LCR.


Increased PVI was independently correlated with higher CVD risk based on the FRS, diabetes, and systolic hypertension. Prospective follow up of this cohort is warranted to confirm that PVI is associated with the development of CVD.

Corresponding author: Professor Pedro G. Vidigal, MSc, MD, Department of Clinical Pathology, Universidade Federal de Minas Gerais, Av. Prof. Alfredo Balena, 190, Sala 403, Belo Horizonte, Minas Gerais, CEP 30130-100, Brazil, Phone: +55 31 3409-9774, Fax: +55 31 3409-9782, E-mail:


The authors thank the staff and participants of the ELSA study for their important contributions. This manuscript was reviewed by a professional science editor and by a native English-speaking copy editor to improve readability.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: The ELSA-Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department DECIT) and the Brazilian Ministry of Science and Technology (FINEP, Financiadora de Estudos e Projetos and CNPq, National Research Council), grants 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ. SMB is a research fellow of the National Research Council (CNPq, grant number 300159/99-4).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2015-7-17
Accepted: 2015-10-6
Published Online: 2015-11-17
Published in Print: 2016-5-1

©2016 Walter de Gruyter GmbH, Berlin/Boston

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