Accessible Unlicensed Requires Authentication Published by De Gruyter September 19, 2015

Marked elevation of procalcitonin in a patient with a drug related infusion reaction to rituximab

Christoph Robier, Manfred Neubauer and Gerhard Reicht

Corresponding author: Christoph Robier, MD, Central Laboratory, Hospital of the Brothers of St. John of God, Graz, Bergstr. 27, 8020 Graz, Austria, Phone: +43 316 5989 6671, Fax +43 316 5989 1505, E-mail: ; and Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria


1. Bouadma L, Luyt CE, Tubach F, Cracco C, Alvarez A, Schwebel C, et al. Use of procalcitonin to reduce patients’ exposure to antibiotics in intensive care units (PRORATA trial): a multicentre randomised controlled trial. Lancet 2010;375:463–74.Search in Google Scholar

2. Meisner M. Update on procalcitonin measurements. Ann Lab Med 2014;34:263–73.Search in Google Scholar

3. Sfia M, Boeckler P, Lipsker D. High procalcitonin levels in patients with severe drug reactions. Arch Dermatol 2007;143:1591.Search in Google Scholar

4. Hounoki H, Yamaguchi S, Taki H, Okumura M, Shinoda K, Tobe K. Elevated serum procalcitonin in anaphylaxis. J Antimicrob Chemother 2013;68:1689–90.Search in Google Scholar

5. Bonaci-Nikolic B, Jeremic I, Nikolic M, Andrejevic S, Lavadinovic L. High procalcitonin in a patient with drug hypersensitivity syndrome. Inter Med 2009;48:1471–4.Search in Google Scholar

6. Cantarin-Extremera V, Castano-De La Mota C, Alvarez-Coca J, Rojas MR, Gutierrez-Solana LG, Garcia Penas JJ, et al. Procalcitonin, a high acute phase reactant in antiepileptic hypersensitivity syndrome in pediatric age. Eur J Paediatr Neurol 2012;16:200–2.Search in Google Scholar

7. Matwiyoff GN, Prahl JD, Miller RJ, Carmichael JJ, Amundson DE, Seda G, et al. Immune regulation of procalcitonin: a biomarker and mediator of infection. Inflamm Res 2012;61:401–9.Search in Google Scholar

8. Stone SF, Cotterell C, Isbister GK, Holdgate A, Brown SG. Elevated serum cytokines during human anaphylaxis: identification of potential mediators of acute allergic reactions. J Allergy Clin Immunol 2009;124:786–92.Search in Google Scholar

9. Jäger U, Fridrik M, Zeitlinger M, Heintel, D, Hopfinger G, Burgstaller S, et al. Rituximab serum concentrations during immuno-chemotherapy of follicular lymphoma correlate with patient gender, bone marrow infiltration and clinical response. Haematologica 2012;97:1431–8.Search in Google Scholar

10. Mann J, Cavallazzi R. Marked serum procalcitonin level in response to isolated anaphylactic shock. Am J Emerg Med 2015;33:125.e5–6.Search in Google Scholar

Received: 2015-8-10
Accepted: 2015-8-29
Published Online: 2015-9-19
Published in Print: 2016-3-1

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