Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter June 8, 2016

Plasminogen activator inhibitor-1 as a marker of cardiovascular response in professional mountain ultra-marathon runners

  • Giovanni Lombardi EMAIL logo , Gianluca Vernillo , Veronica Sansoni , Silvia Perego , Andrea Barbuti , Giampiero Merati , Federico Schena , Giuseppe Banfi and Antonio La Torre

Corresponding author: Giovanni Lombardi, PhD, Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, 20161 Milan, Italy, Phone/Fax: 00390266214068

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: Ministero della Salute.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med 2012;10:77.10.1186/1741-7015-10-77Search in Google Scholar PubMed PubMed Central

2. Yamamoto K, Takeshita K, Saito H. Plasminogen activator inhibitor-1 in aging. Semin Thromb Hemost 2014;40:652–9.10.1055/s-0034-1384635Search in Google Scholar PubMed

3. American College of Sports Medicine. ACSM’s Guidelines for Exercise Testing and Prescription, 8th ed. Philadephia, PA: Wolters Kluwer/Lippincott Williams & Wilkins, 2010.Search in Google Scholar

4. Galliera E, Lombardi G, Marazzi MG, Grasso D, Vianello E, Pozzoni R, et al. Acute exercise in elite rugby players increases the circulating level of the cardiovascular biomarker GDF-15. Scand J Clin Lab Invest 2014;74:492–9.10.3109/00365513.2014.905697Search in Google Scholar PubMed

5. Corsetti R, Lombardi G, Barassi A, Lanteri P, Colombini A, Melzi d’Eril G, et al. Cardiac indexes, cardiac damage biomarkers and energy expenditure in professional cyclists during the Giro d’Italia 3-weeks stage race. Biochem Med 2012;22:237–46.10.11613/BM.2012.026Search in Google Scholar

6. Lippi G, Cervellin G, Banfi G, Plebani M. Cardiac troponins and physical exercise. It’s time to make a point. Biochem Med 2011;21:55–62.10.11613/BM.2011.012Search in Google Scholar PubMed

7. Eijsvogels TM, Molossi S, Lee DC, Emery MS, Thompson PD. Exercise at the Extremes: the amount of exercise to reduce cardiovascular events. J Am Coll Cardiol 2016;67:316–29.10.1016/j.jacc.2015.11.034Search in Google Scholar PubMed

8. Lippi G, Schena F, Salvagno GL, Montagnana M, Gelati M, Tarperi C, et al. Influence of a half-marathon run on NT-proBNP and troponin T. Clin Lab 2008;54:251–4.Search in Google Scholar

9. Banfi G, Lippi G, Susta D, Barassi A, D’Eril GM, Dogliotti G, et al. NT-proBNP concentrations in mountain marathoners. J Strength Cond Res 2010;24:1369–72.10.1519/JSC.0b013e3181d1562dSearch in Google Scholar PubMed

10. Yamamoto K, Takeshita K, Kojima T, Takamatsu J, Saito H. Aging and plasminogen activator inhibitor-1 (PAI-1) regulation: implication in the pathogenesis of thrombotic disorders in the elderly. Cardiovasc Res 2005;66:276–85.10.1016/j.cardiores.2004.11.013Search in Google Scholar PubMed

Received: 2016-4-11
Accepted: 2016-5-7
Published Online: 2016-6-8
Published in Print: 2017-1-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 7.2.2023 from https://www.degruyter.com/document/doi/10.1515/cclm-2016-0295/html
Scroll Up Arrow