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Licensed Unlicensed Requires Authentication Published by De Gruyter August 13, 2016

How to define reference intervals to rule in healthy individuals for clinical trials?

Wendy P.J. den Elzen EMAIL logo , Joop van Gerven , Paul W. Schenk , Anna Uit Den Boogaard , Ria Kroon , Erica Klaassen , Bart E.P.B. Ballieux and Christa M. Cobbaert

Corresponding author: Wendy P.J. den Elzen, PhD, Department of Clinical Chemistry and Laboratory Medicine, Leiden University Medical Center, Postal zone E2-P, 2300 RC, Leiden, The Netherlands, Phone: +31 71 526 2278

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. All authors confirmed they have contributed to the intellectual content of this paper and have met the following three requirements: (a) significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; (b) drafting or revising the article for intellectual content; and (c) final approval of the published article.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


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Received: 2016-4-13
Accepted: 2016-7-20
Published Online: 2016-8-13
Published in Print: 2017-3-1

©2017 Walter de Gruyter GmbH, Berlin/Boston

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