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Accessible Unlicensed Requires Authentication Published by De Gruyter November 10, 2016

25-Hydroxyvitamin D threshold values should be age-specific

Lilian Mello Soares, William Pedrosa, Silvana Maria Elói-Santos and Leonardo Souza Vasconcellos

Corresponding author: Lilian Mello Soares, MD, MSc, Hermes Pardini Laboratory, Av. Contorno, 3825, 4o. andar, Funcionários, Belo Horizonte, Minas Gerais 30110-021, Brazil, Phone: +55-31-999825578

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: LMS and WP are employed by Hermes Pardini Laboratory (Belo Horizonte, MG, Brazil). SMES and LSV have nothing to disclose.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Ross AC, Taylor CL, Yaktine AL, Del Valle HB, editors. Dietary reference intakes for calcium and vitamin D. Washington, DC: National Academies Press, 2011:1115.Search in Google Scholar

2. Adams JS, Hewison M. Update in vitamin D. J Clin Endocrinol Metab 2010;95:471–8.Search in Google Scholar

3. Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 2011;96:1911–30.Search in Google Scholar

4. Valcour A, Blocki F, Hawkins DM, Rao SD. Effects of age and serum 25-OH-vitamin D on serum parathyroid hormone levels. J Clin Endocrinol Metab 2012;97:3989–95.Search in Google Scholar

5. Chapuy MC, Preziosi P, Maamer M, Arnaud S, Galan P, Hercberg S, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int 1997;7:439–43.Search in Google Scholar

6. Vieth R, Ladak Y, Walfish PG. Age-related changes in the 25-hydroxyvitamin D versus parathyroid hormone relationship suggest a different reason why older adults require more vitamin D. J Clin Endocrinol Metab 2003;88:185–91.Search in Google Scholar

7. Arabi A, Baddoura R, El-Rassi R, El-Hajj Fuleihan G. Age but not gender modulates the relationship between PTH and vitamin D. Bone 2010;47:408–12.Search in Google Scholar

8. Pattanaungkul S, Riggs BL, Yergey AL, Vieira NE, O’Fallon WM, Khosla S. Relationship of intestinal calcium absorption to 1,25-dihydroxyvitamin D [1,25(OH)2D] levels in young versus elderly women: evidence for age-related intestinal resistance to 1,25(OH)2D action. J Clin Endocrinol Metab 2000;85:4023–7.Search in Google Scholar

9. Kinyamu HK, Gallagher JC, Prahl JM, DeLuca HF, Petranick KM, Lanspa SJ. Association between intestinal vitamin D receptor, calcium absorption, and serum 1,25 dihydroxyvitamin D in normal young and elderly women. J Bone Miner Res 1997;12:922–8.Search in Google Scholar

10. Adami S, Viapiana O, Gatti D, Idolazzi L, Rossini M. Relationship between serum parathyroid hormone, vitamin D sufficiency, age, and calcium intake. Bone 2008;42:267–70.Search in Google Scholar

Received: 2016-9-6
Accepted: 2016-10-7
Published Online: 2016-11-10
Published in Print: 2017-6-27

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