Acknowledgments
The authors thank Stefano Gentili, Michele Sciotti, Simonetta di Carlo, Antonella Bacosi and Laura Martucci for their technical assistance.
Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.
Research funding: Funded by the project: “Implementazione dei Sistemi di Sorveglianza sul disturbo da gioco d’azzardo e sull’uso medico della cannabis sul territorio Nazionale” by the Ministry of Health.
Employment or leadership: None declared.
Honorarium: None declared.
Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.
References
1. Decreto 9 novembre 2015: Funzioni di Organismo statale per la cannabis previsto dagli articoli 23 e 28 della convenzione unica sugli stupefacenti del 1961, come modificata nel 1972. Available at: http://www.gazzettaufficiale.it/eli/id/2015/11/30/15A08888/sg;jsessionid=p1rnwNujUKlqQ5azhAQ95A__.ntc-as3-guri2a. Accessed: 24 Aug 2017.Search in Google Scholar
2. Pacifici R, Marchei E, Salvatore F, Guandalini L, Busardò FP, Pichini S. Evaluation of cannabinoids concentration and stability in standardized preparations of cannabis tea and cannabis oil by ultra-high performance liquid chromatography tandem mass spectrometry. Clin Chem Lab Med 2017;55:1555–63. [Epub ahead of print].10.1515/cclm-2016-1060Search in Google Scholar PubMed
3. Trofin IG, Dabija G, Váireanu DI, Filipescu L. The influence of long-term storage conditions on the stability of cannabinoids derived from cannabis resin. Rev Chim 2012;63:422–7.Search in Google Scholar
4. Trofin IG, Dabija G, Váireanu DI, Filipescu L. Long term storage and cannabis oil stability. Rev Chim 2012;63:293–7.Search in Google Scholar
5. Taschwer M, Schmid MG. Determination of the relative percentage distribution of THCA and Δ(9)-THC in herbal cannabis seized in Austria – Impact of different storage temperatures on stability. Forensic Sci Int 2015;254:167–71.10.1016/j.forsciint.2015.07.019Search in Google Scholar PubMed
6. Lindholst C. Long term stability of cannabis resin and cannabis extracts. Australian J Forensic Sci 2010;42:181–90.10.1080/00450610903258144Search in Google Scholar
7. Rock EM, Limebeer CL, Parker LA. Effect of combined doses of Δ(9)-tetrahydrocannabinol (THC) and cannabidiolic acid (CBDA) on acute and anticipatory nausea using rat (Sprague-Dawley) models of conditioned gaping. Psychopharmacology 2015;232:4445–4.10.1007/s00213-015-4080-1Search in Google Scholar PubMed
8. Brierley DI, Samuels J, Duncan M, Whalley BJ, Williams CM. Neuromotor tolerability and behavioural characterisation of cannabidiolic acid, a phytocannabinoid with therapeutic potential for anticipatory nausea. Psychopharmacology 2016;233:243–54.10.1007/s00213-015-4100-1Search in Google Scholar PubMed
9. Carbone M, Castelluccio F, Daniele A, Sutton A, Ligresti A, Di Marzo V, et al. Chemical characterisation of oxidative degradation products of Δ9-THC. Tetrahedron 2010;66:9497–501.10.1016/j.tet.2010.10.025Search in Google Scholar
©2018 Walter de Gruyter GmbH, Berlin/Boston
