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Accessible Unlicensed Requires Authentication Published by De Gruyter January 5, 2018

Rational approach to the primary evaluation of thyroid disease in paediatrics. Full thyroid profile vs. thyroid-stimulating hormone and free thyroxine only

Verónica Zaidman, Juan Manuel Lazzati, Mercedes Maceiras, Viviana Herzovich, Melina Pelanda, Alejandra Ribas, Alicia Belgorosky and Eduardo A. Chaler

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Fryer AA, Smellie WS. Managing demand for laboratory tests: a laboratory toolkit. J Clin Pathol 2013;66:62–72.Search in Google Scholar

2. Jackson BR. Managing laboratory test use: principles and tools. Clin Lab Med 2007; 27:733–48.Search in Google Scholar

3. Investigation and management of primary thyroid dysfunction clinical practice guideline. Edmonton, AB, Canada: Toward Optimized Practice, 2014. Available at: . Accessed: 16 Nov 2017.Search in Google Scholar

4. Gill J, Barakauskas VE, Thomas D, Rodriguez-Capote K, Higgins T, Zhang D, et al. Evaluation of thyroid test utilization through analysis of population-level data. Clin Chem Lab Med 2017;56: 1898–906.Search in Google Scholar

5. American Society for Clinical Pathology Choosing Wisely Recommendations, 2015. Available at: . Accessed: 3 Jul 2016.Search in Google Scholar

6. Schoenmakers N, Alatzoglou KS, Chatterjee VK, Dattani MT. Recent advances in central congenital hypothyroidism. J Endocrinol 2015;22:R51–71.Search in Google Scholar

7. Persani L. Central hypothyroidism: pathogenic, diagnostic and therapeutic challenges. J Clin Endocrinol Metab 2012;97:3068–78.Search in Google Scholar

8. Chaler EA, Fiorenzano R, Chilelli C, Llinares V, Areny G, Herzovich V, et al. Age-specific thyroid hormone and thyrotropin reference intervals for a pediatric and adolescent population. Clin Chem Lab Med 2012;50:885–90.Search in Google Scholar

9. Elmlinger MW, Kühnel W, Lambrecht H-G, Ranke MB. Reference intervals from birth to adulthood for serum thyroxine (T4), triiodothyronine (T3), free T3, thyroxine binding globulin (TBG) and thyrotropin (TSH). Clin Chem Lab Med 2001;39:973–9.Search in Google Scholar

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Received: 2017-10-19
Accepted: 2017-11-20
Published Online: 2018-1-5
Published in Print: 2018-5-24

©2018 Walter de Gruyter GmbH, Berlin/Boston