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Licensed Unlicensed Requires Authentication Published by De Gruyter May 1, 2018

Unstable haemoglobin variant Hb Leiden is detected on Sysmex XN-Series analysers

  • Wesley Jongbloed EMAIL logo , Gitte van Twillert , Margreet Schoorl and Roger K. Schindhelm


The authors thank Dr. C.L. Harteveld of the Haemoglobinopathies Laboratory in Leiden, The Netherlands, for performing the DNA analysis. The patient consented in publishing this case report.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Edward HL, Pisani LA, Rodriguez-Romero WE, Chaves-Villalobos J, Garcia-Quesada J, Harris NS, et al. Hb Youngstown (beta101(G3)Glu→Ala; HBB: c.305A>C: an unstable hemoglobin variant causing severe hemolytic anemia. Hemoglobin 2014;38:381–4.10.3109/03630269.2014.971960Search in Google Scholar PubMed

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Received: 2018-01-12
Accepted: 2018-03-06
Published Online: 2018-05-01
Published in Print: 2018-08-28

©2018 Walter de Gruyter GmbH, Berlin/Boston

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