Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 15, 2019

Comparison of precision and operational performances across six immunochemistry analyzers

Peter Findeisen EMAIL logo , Ingrid Zahn , Carmen Garcia Rabaneda , David Krempel , Maria Teresa Haro Romero , Tomas De Haro-Muñoz , Mikel Barral Juez , Kai Klopprogge and Sabine Engelmann

Corresponding author: Prof. Dr med. Peter Findeisen, Laboratory Dr. Limbach and Colleagues, Im Breitspiel 16, 69126 Heidelberg, Germany


The authors wish to thank their staff at the respective sites for the professional and dedicated support throughout the study. For study monitoring and support at Roche Diagnostics, we thank C. Stieber, B. Schneider, A. Sofianidis, I. Erber, H. Sauter, S. Mathis, as well as H. Peuker (Biomedical Investigation Services) for the manuscript preparation.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This non-interventional multicenter study was designed and sponsored by Roche Diagnostics GmbH, Mannheim. cobas, cobas E, cobaS C, ELECSYS are trademarks of Roche.

  3. Employment or leadership: S. Engelmann and K. Klopprogge are employees of Roche Diagnostics GmbH.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Rohr UP, Binder C, Dieterle T, Giusti F, Messina CG, Toerien E, et al. The value of in vitro diagnostic testing in medical practice: a status report. PLoS One 2016;11:e0149856.10.1371/journal.pone.0149856Search in Google Scholar PubMed PubMed Central

2. Plebani M. Clinical laboratories: production industry or medical services? Clin Chem Lab Med 2015;53:995–1004.10.1515/cclm-2014-1007Search in Google Scholar PubMed

3. Barletta G, Zaninotto M, Faggian D, Plebani M. Shop for quality or quantity? Volumes and costs in clinical laboratories. Clin Chem Lab Med 2013;51:295–301.10.1515/cclm-2012-0415Search in Google Scholar PubMed

4. Lippi G, Plebani M. Laboratory economics. Risk or opportunity? Clin Chem Lab Med 2016;54:1701–3.10.1515/cclm-2016-0313Search in Google Scholar PubMed

5. Findeisen P, Zahn I, Fiedler GM, Leichtle AB, Wang S, Soria G, et al. Doubling immunochemistry laboratory testing efficiency with the cobas e 801 module while maintaining consistency in analytical performance. Clin Biochem 2018;58: 86–93.10.1016/j.clinbiochem.2018.05.019Search in Google Scholar PubMed

6. Fruttero ER, Picciolo G, De Matteis JA. Operative performances and efficiency for infectious disease testing of two immunochemistry analyzers – Abbott ARCHITECT i2000SR and DiaSorin Liaison XL. Clin Chem Lab Med 2015;53:e19–23.10.1515/cclm-2014-0499Search in Google Scholar PubMed

7. Ricós FindeisenC, Alvarez V, Cava F, García-Lario JV, Hernández A, Jiménez CV, et al. Desirable specifications for total error, imprecision, and bias, derived from intra- and inter-individual biologic variation. The 2014 update. Available at: Accessed: August 2018.Search in Google Scholar

Received: 2018-11-29
Accepted: 2019-02-13
Published Online: 2019-03-15
Published in Print: 2019-09-25

©2019 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 26.1.2023 from
Scroll Up Arrow