Accessible Requires Authentication Published by De Gruyter June 27, 2019

Mozhaisk haemoglobin variant effects on leukocyte differential channel using the Sysmex XN series

Valentina Moioli, Michela Seghezzi, Giulia Previtali, Maria D.C. Baigorria, Paola Dominoni, Laura Michetti, Massimo Provenzi, Eugenia Giraldi, Carlo Foglia and Sabrina Buoro

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Hardison RC, Chui DH, Giardine B, Riemer C, Patrinos GP, Anagnou N, et al. HbVar: a relational database of human hemoglobin variants and thalassemia mutations at the globin gene server. Hum Mutat 2002;19:225–33. Search in Google Scholar

2. Rosetti M, Poletti G, Sensi A, Ravani A, Rondoni M, Baldrati L, et al. A rare case of hemoglobin Leiden interfering with the DIFF channel of Sysmex XE-2100. Scand J Clin Lab Invest 2015;75: 436–7. Search in Google Scholar

3. Jongbloed W, Van Twillert G, Schoorl M, Schindhelm RK. Unstable haemoglobin variant Hb Leiden is detected on Sysmex XN-series analysers. Clin Chem Lab Med 2018;56:e249–50. Search in Google Scholar

4. Schapkaitz E, Raburabu S. Performance evaluation of the new measurement channels on the automated Sysmex XN-9000 hematology analyzer. Clin Biochem 2018;53:132–8. Search in Google Scholar

5. Barnes PW, McFadden L, Machin SJ, Simson E, International Consensus Group for Hematology. The international consensus group for hematology review: suggested criteria for action following automated CBC and WBC differential analysis. Lab Hematol 2005;11:83–90. Search in Google Scholar

6. Benzoni E, Giannone V, Michetti L, Seia M, Cavalleri L, Curcio C. Hb Mozhaisk [β92(F8)His→Arg; HBB: c.278A>G] as a de novo mutation in a child of mixed ethnic origins. Hemoglobin 2017;41:314–6. Search in Google Scholar

7. Spivak VA, Molchanova TP, Postnikov YuV, Aseeva EA, Lutsenko IN, Tokarev YuN. A new abnormal hemoglobin: Hb Mozhaisk beta 92(F8) His leads to Arg. Hemoglobin 1982;6: 169–81. Search in Google Scholar

8. Bird AR, Elliott T, Wilson JB, Webber BB, Hu H, Kutlar A, et al. Two rare unstable beta chain variants, Hb Mozhaisk or alpha 2 beta 292(F8) His–Arg and Hb Djelfa or alpha 2 beta 298(Fg5)Val–Ala, each being observed for the second time. Hemoglobin 1989;13:193–7. Search in Google Scholar

Received: 2019-04-06
Accepted: 2019-05-27
Published Online: 2019-06-27
Published in Print: 2019-11-26

© 2019 Walter de Gruyter GmbH, Berlin/Boston