Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter February 29, 2020

Macro-aspartate aminotransferase syndrome: a case report

Hao Mingju , Wang Minyu , Ge Xiaoxiao , Lu Sumei , Ma Jianping and Ma Wanshan EMAIL logo

Corresponding author: Ma Wanshan, PhD, Department of Laboratory Medicine, Shandong Provincial Qianfoshan Hospital, Shandong University, 16766 Jingshi Road, Jinan, Shandong Province, P.R. China, Phone: +86-531-89269673
aHao Mingju and Wang Minyu contributed equally to this work.

Acknowledgments

We are grateful to our colleagues Sun Tao, Meng Qingsong for measuring the immunoglobulin subclass on the Siemens platform.

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.

References

1. Lee M, Vajro P, Keeffe EB. Isolated aspartate aminotransferase elevation: think macro-AST. Dig Dis Sci 2011;56:311–3.10.1007/s10620-011-1575-4Search in Google Scholar

2. Konttinen A, Murros J, Ojala K, Salaspuro M, Somer H, Rasanen J. A new cause of increased serum aspartate aminotransferase activity. Clin Chim Acta 1978;84:145–7.10.1016/0009-8981(78)90487-4Search in Google Scholar

3. Agrawal S, Dhiman RK, Limdi JK. Evaluation of abnormal liver function tests. Postgrad Med J 2016;92:223–34.10.1136/postgradmedj-2015-133715Search in Google Scholar PubMed

4. Krishnamurthy S, Korenblat KM, Scott MG. Persistent increase in aspartate aminotransferase in an asymptomatic patient. Clin Chem 2009;55:1573–5.10.1373/clinchem.2008.120782Search in Google Scholar PubMed

5. van Wijk XM, Magee CA, Wu AH, Tana MM, Lynch KL. A comparison of methods for evaluation of a case of suspected macro-aspartate aminotransferase. Clin Chim Acta 2016;463:1–3.10.1016/j.cca.2016.10.011Search in Google Scholar PubMed

6. Schumann G, Canalias F, Joergensen PJ, Kang D, Lessinger JM, Klauke R, et al. IFCC reference procedures for measurement of the catalytic concentrations of enzymes: corrigendum, notes and useful advice. International Federation of Clinical Chemistry and Laboratory Medicine (IFCC)–IFCC Scientific Division. Clin Chem Lab Med 2010;48: 615–21.Search in Google Scholar

7. Orlando R, Carbone A, Lirussi F. Macro-aspartate aminotransferase (macro-AST). A 12-year follow-up study in a young female. Eur J Gastroenterol Hepatol 2003;15:1371–3.10.1097/00042737-200312000-00018Search in Google Scholar PubMed

8. Asanuma K, Yagihashi A, Watanabe N. Characterization of the aspartate aminotransferase-immunoglobulin M complex in a Japanese woman. Clin Chem 1997;43:686–7.10.1093/clinchem/43.4.686Search in Google Scholar

9. Chew-Harris JS, Brennan SO, Florkowski CM, Troughton R, George PM. Deciphering a macro-troponin I complex; a case report. Clin Chem Lab Med 2017;55:e77–9.10.1515/cclm-2016-0490Search in Google Scholar PubMed

10. Kulecka M, Wierzbicka A, Paziewska A, Mikula M, Habior A, Janczyk W, et al. A heterozygous mutation in GOT1 is associated with familial macro-aspartate aminotransferase. J Hepatol 2017;67:1026–30.10.1016/j.jhep.2017.07.003Search in Google Scholar PubMed

11. Werner T, Vargas HE, Chalasani N. Macro-aspartate aminotransferase and monoclonal gammopathy: a review of two cases. Dig Dis Sci 2007;52:1197–8.10.1007/s10620-006-9555-9Search in Google Scholar PubMed

12. Triester SL, Douglas DD. Development of macro-aspartate aminotransferase in a patient undergoing specific allergen injection immunotherapy. Am J Gastroenterol 2005;100:243–5.10.1111/j.1572-0241.2005.41284.xSearch in Google Scholar PubMed

13. Chung YW, Sohn JH, Baek CH, Kim JP, Jeon YC, Han DS, et al. Macro-aspartate aminotransferase in a patient with chronic hepatitis C. Korean J Gastroenterol 2006;47:229–32.Search in Google Scholar

14. Lartigau-Roussin C, Paclet MH, Audin H, Toussaint B, Henni T, Raffray L. Macro-AST and myeloma: An incidental association? Rev Med Intern 2017;38:210–3.10.1016/j.revmed.2016.05.015Search in Google Scholar PubMed

15. Stasia MJ, Surla A, Renversez JC, Pene F, Morel-Femelez A, Morel F. Aspartate aminotransferase macroenzyme complex in serum identified and characterized. Clin Chem 1994;40:1340–3.10.1093/clinchem/40.7.1340Search in Google Scholar

16. Caropreso M, Fortunato G, Lenta S, Palmieri D, Esposito M, Vitale DF, et al. Prevalence and long-term course of macro-aspartate aminotransferase in children. J Pediatr 2009;154:744–8.10.1016/j.jpeds.2008.11.010Search in Google Scholar PubMed

17. Castiella A, Aguayo FJ, Rueda M, Fernandez J, Zapata E. Macroaspartate aminotransferase (macro-AST) a rare cause of hipertransaminasemia: another way to diagnosis? J Clin Gastroenterol 2006;40:655.10.1097/00004836-200608000-00024Search in Google Scholar PubMed

18. Yu Z, Wang Y, Feng L, Jia J. Macro-aspartate aminotransferase: two-year follow-up of three patients in China. Dig Dis Sci 2014;59:224–6.10.1007/s10620-013-2856-xSearch in Google Scholar PubMed

19. Haskova V, Kaslik J, Riha I, Matl I, Rovensky J. Simple method of circulating immune complex detection in human sera by polyethylene glycol precipitation. Z Immunitatsforsch Immunobiol 1978;154:399–406.Search in Google Scholar

20. Davidson DF, Watson DJ. Macroenzyme detection by polyethylene glycol precipitation. Ann Clin Biochem 2003;40:514–20.10.1258/000456303322326425Search in Google Scholar PubMed

21. Collins J, Ritter D, Bacon BR, Landt M, Creer MH. Macro-aspartate aminotransferase in a female with antibodies to hepatitis C virus. Liver 2002;22:501–6.10.1034/j.1600-0676.2002.01689.xSearch in Google Scholar PubMed

22. Beser OF, Lacinel S, Gulcu D, Kutlu T, Cullu Cokugras F, Erkan T. An easy method for diagnosing macro-aspartate aminotransferase: a case series. Turk J Gastroenterol 2014;25:568–70.10.5152/tjg.2014.7504Search in Google Scholar PubMed

23. Bjorck L, Kronvall G. Purification and some properties of streptococcal protein G, a novel IgG-binding reagent. J Immunol 1984;133:969–74.Search in Google Scholar

24. Sasso EH, Silverman GJ, Mannik M. Human IgM molecules that bind staphylococcal protein A contain VHIII H chains. J Immunol 1989;142:2778–83.Search in Google Scholar

Received: 2019-06-17
Accepted: 2019-07-22
Published Online: 2020-02-29
Published in Print: 2020-03-26

©2020 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 8.12.2022 from https://www.degruyter.com/document/doi/10.1515/cclm-2019-0618/html
Scroll Up Arrow