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Licensed Unlicensed Requires Authentication Published by De Gruyter November 12, 2019

Detection of Hb Phnom Penh by matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry during the measurement of glycated hemoglobin

  • Anping Xu ORCID logo , Yajun Wang , Jie Li , Weijie Xie , Weidong Chen EMAIL logo and Ling Ji EMAIL logo
  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  2. Research funding: This study was supported by Research Foundation of Peking University Shenzhen Hospital (JCYJ2018005).

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The funding organization(s) played no role in the study design; in the collection, analysis, and interpretation of data; in the writing of the report; or in the decision to submit the report for publication.


1. Xu A, Chen W, Xia Y, Zhou Y, Ji L. Effects of common hemoglobin variants on HbA1c measurements in China: results for α- and β-globin variants measured by six methods. Clin Chem Lab Med 2018;56:1353–61.10.1515/cclm-2017-1211Search in Google Scholar PubMed

2. Xu A, Wang Y, Li J, Liu G, Li X, Chen W, et al. Evaluation of MALDI-TOF MS for the measurement of glycated hemoglobin. Clin Chim Acta 2019;498:154–60.10.1016/j.cca.2019.08.025Search in Google Scholar PubMed

3. Rohlfing C, Hanson S, Weykamp C, Siebelder C, Higgins T, Molinaro R, et al. Effects of hemoglobin C, D, E and S traits on measurements of hemoglobin A1c by twelve methods. Clin Chim Acta 2016;455:80–3.10.1016/j.cca.2016.01.031Search in Google Scholar PubMed PubMed Central

4. Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993;329:977–86.10.1056/NEJM199309303291401Search in Google Scholar PubMed

5. Roberts NB, Amara AB, Morris M, Green BN. Long-term evaluation of electrospray ionization mass spectrometric analysis of glycated hemoglobin. Clin Chem 2001;47:316–21.10.1093/clinchem/47.2.316Search in Google Scholar

6. Hattan SJ, Parker KC, Vestal ML, Yang JY, Herold DA, Duncan MW. Analysis and quantitation of glycated hemoglobin by matrix assisted laser desorption/ionization time of flight mass spectrometry. J Am Soc Mass Spectrom 2016;27:532–41.10.1007/s13361-015-1316-6Search in Google Scholar PubMed

Supplementary Material

The online version of this article offers supplementary material (

Received: 2019-09-03
Accepted: 2019-10-16
Published Online: 2019-11-12
Published in Print: 2020-09-25

©2019 Walter de Gruyter GmbH, Berlin/Boston

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