Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter February 17, 2020

Reference intervals for clinically reportable platelet parameters on the Mindray BC-6800Plus hematology analyzer

  • Hanah Kim , Mina Hur EMAIL logo , Seung-Wan Kim , Hee-Won Moon and Yeo-Min Yun

Corresponding author: Mina Hur, MD, PhD, Department of Laboratory Medicine, Konkuk University School of Medicine, Konkuk University Medical Center, 120-1, Neungdong-ro, Hwayang-dong, Gwangjin-gu, Seoul 05030, Korea, Phone: +82-2-2030-5581, Fax: +82-2-2636-6764

  1. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission. H. Kim analyzed the data and wrote the draft; M. Hur designed the study and finalized the draft; S.W. Kim participated in data collection; H.W. Moon and Y.M. Yun participated in data analysis and reviewed the draft.

  2. Research funding: None declared.

  3. Employment or leadership: None declared.

  4. Honorarium: None declared.

  5. Competing interests: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.


1. Cho SY, Hur M. Expanded impacts of platelet functions: beyond hemostasis and thrombosis. Ann Lab Med 2019;39:343–4.10.3343/alm.2019.39.4.343Search in Google Scholar PubMed PubMed Central

2. Lippi G, Pavesi F, Pipitone S. Evaluation of mean platelet volume with four hematological analyzers: harmonization is still an unresolved issue. Blood Coagul Fibrinolysis 2015;26:235–7.10.1097/MBC.0000000000000220Search in Google Scholar PubMed

3. Clinical and Laboratory Standards Institute. Defining, establishing, and verifying reference intervals in the clinical laboratory; approved guideline, 3rd ed. CLSI document EP28-A3C. Wayne, PA: Clinical and Laboratory Standards Institute, 2010.Search in Google Scholar

4. Ko YJ, Hur M, Kim H, Choi SG, Moon HW, Yun YM. Reference interval for immature platelet fraction on Sysmex XN hematology analyzer: a comparison study with Sysmex XE-2100. Clin Chem Lab Med 2015;53:1091–7.10.1515/cclm-2014-0839Search in Google Scholar PubMed

5. Ozarda Y, Sikaris K, Streichert T, Macri J, IFCC Committee on Reference Intervals and Decision Limits (C-RIDL). Distinguishing reference intervals and clinical decision limits – a review by the IFCC committee on reference intervals and decision limits. Crit Rev Clin Lab Sci 2018;55:420–31.10.1080/10408363.2018.1482256Search in Google Scholar PubMed

6. van der Linden N, Klinkenberg LJ, Meex SJ, Beckers EA, de Wit NC, Prinzen L. Immature platelet fraction measured on the Sysmex XN hemocytometer predicts thrombopoietic recovery after autologous stem cell transplantation. Eur J Haematol 2014;93:150–6.10.1111/ejh.12319Search in Google Scholar PubMed PubMed Central

7. Buoro S, Seghezzi M, Manenti B, Pacioni A, Carobene A, Ceriotti F, et al. Biological variation of platelet parameters determined by the Sysmex XN hematology analyzer. Clin Chim Acta 2017;470:125–32.10.1016/j.cca.2017.05.004Search in Google Scholar PubMed

8. Buttarello M, Mezzapelle G, Plebani M. Effect of preanalytical and analytical variables on the clinical utility of mean platelet volume. Clin Chem Lab Med 2018;56:718–25.10.1515/cclm-2017-0730Search in Google Scholar PubMed

9. Hoffmann JJ, van den Broek NM, Curvers J. Reference intervals of reticulated platelets and other platelet parameters and their associations. Arch Pathol Lab Med 2013;137:1635–40.10.5858/arpa.2012-0624-OASearch in Google Scholar PubMed

10. Coskun A, Braga F, Carobene A, Tejedor Ganduxe X, Aarsand AK, Fernández-Calle P, et al. Systematic review and meta-analysis of within-subject and between-subject biological variation estimates of 20 haematological parameters. Clin Chem Lab Med 2019;58:25–32.10.1515/cclm-2019-0658Search in Google Scholar PubMed

Received: 2020-01-08
Accepted: 2020-01-22
Published Online: 2020-02-17
Published in Print: 2020-09-25

©2020 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 2.6.2023 from
Scroll to top button