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Plasma xanthine oxidoreductase activity change over 12 months independently associated with change in serum uric acid level: MedCity21 health examination registry

  • Masafumi Kurajoh EMAIL logo , Shinya Fukumoto , Takayo Murase , Takashi Nakamura , Yuki Nagata , Shinya Nakatani , Akihiro Tsuda , Shinsuke Yamada , Tomoaki Morioka , Katsuhito Mori , Yasuo Imanishi , Norifumi Kawada , Kazuto Hirata and Masanori Emoto

Corresponding author: Masafumi Kurajoh, MD, PhD, Department of Metabolism, Endocrinology, and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, 545-8585, Osaka, Japan, Phone: +81-6-6645-3806, Fax: +81-6-6645-3808, E-mail:

Funding source: Sanwa Kagaku Kenkyusho

Funding source: Takeda Pharmaceuticals

Funding source: Astellas Pharma

Funding source: Gout Research Foundation

Funding source: JSPS KAKENHI

Award Identifier / Grant number: 18K11132

  1. Research funding: This study was supported in part by research grants from Sanwa Kagaku Kenkyusho (to M.K.), Taisho Toyama Pharmaceutical Co. (to S.F.), Takeda Pharmaceuticals (to S.F.), Mitsubishi Tanabe Pharma Corporation (to S.F.), Chugai Pharmaceutical Co. (to S.F.) and Astellas Pharma (to S.F.), as well the Osaka City University (OCU) Strategic Research Grant 2014, 2015, 2016 for top priority research (to S.F. and K.H.), a grant-in-aid for scientific research from the Gout Research Foundation (to M.K.), and a JSPS KAKENHI grant (number 18K11132) (to S.F.).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: The present study was conducted in full accordance with the Declaration of Helsinki, and the present study protocol was approved by the Ethics Committee of Osaka City University Graduate School of Medicine (approval No. 3684).


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Received: 2020-04-22
Accepted: 2020-06-04
Published Online: 2020-08-01
Published in Print: 2021-03-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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