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Licensed Unlicensed Requires Authentication Published by De Gruyter October 19, 2020

Reference values for plasma neurofilament light chain (NfL) in healthy Chinese

  • Jingshan Chen , Xiaoxia Yang , Ying Zhang , Pei Zheng , Changjuan Wei , Zhifeng Mao , Wenyan He EMAIL logo and Wei-Na Jin EMAIL logo

Corresponding authors: Wei-Na Jin, PhD, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Tiantan Hospital, Capital Medical University, Beijing, P.R. China, E-mail: ; and Wenyan He, PhD, China National Clinical Research Center for Neurological Diseases, Advanced Innovation Center for Human Brain Protection, Beijing Tiantan Hospital, Capital Medical University, Beijing 10070, P.R. China, E-mail:
Jingshan Chen and Xiaoxia Yang contributed equally to this work.

Lead Contact: Wei-Na Jin


Funding source: National Natural Science Foundation of China

Award Identifier / Grant number: 81570095, 91949208, 81971094 and 81771274

  1. Research funding: This study was supported in part by National Science Foundation of China (81570095, 91949208, 81971094 and 81771274).

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: This study was approved by the Ethics Committee of the Beijing Tiantan Hospital (KY2019-050-02) and Tianjin Medical University General Hospital (IRB2019-KY-047).

References

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2. Disanto, G, Barro, C, Benkert, P, Naegelin, Y, Schädelin, S, Giardiello, A, et al. Serum Neurofilament light: a biomarker of neuronal damage in multiple sclerosis. Ann Neurol 2017;81:857–70. https://doi.org/10.1002/ana.24954.Search in Google Scholar PubMed PubMed Central

3. Mattsson, N, Cullen, NC, Andreasson, U, Zetterberg, H, Blennow, K. Association between longitudinal plasma neurofilament light and neurodegeneration in patients with Alzheimer disease. JAMA Neurol 2019;76:791–9. https://doi.org/10.1001/jamaneurol.2019.0765.Search in Google Scholar PubMed PubMed Central

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6. Kuhle, J, Barro, C, Andreasson, U, Derfuss, T, Lindberg, R, Sandelius, Å, et al. Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa. Clin Chem Lab Med 2016;54:1655–61. https://doi.org/10.1515/cclm-2015-1195.Search in Google Scholar PubMed

7. Gisslén, M, Price, RW, Andreasson, U, Norgren, N, Nilsson, S, Hagberg, L, et al. Plasma concentration of the neurofilament light protein (NFL) is a biomarker of CNS injury in HIV infection: a cross-sectional study. EBioMedicine 2015;3:135–40. https://doi.org/10.1016/j.ebiom.2015.11.036.Search in Google Scholar PubMed PubMed Central


Supplementary Material

The online version of this article offers supplementary material (https://doi.org/10.1515/cclm-2020-1030).


Received: 2020-07-05
Accepted: 2020-10-04
Published Online: 2020-10-19
Published in Print: 2021-03-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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