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Licensed Unlicensed Requires Authentication Published by De Gruyter October 19, 2020

Diagnosis of vitamin B12 deficiency: combined indicator of B12-status should be interpreted with caution in the case of renal impairment

  • Geoffrey Urbanski ORCID logo EMAIL logo , Floris Chabrun , Alaa Ghali and Valentin Lacombe

Corresponding author: Geoffrey Urbanski, MD, MSc, Department of Internal Medicine, University Hospital, 4 rue Larrey, 49000 Angers, France, Phone: +33 2 41 35 40 03, Fax: +33 2 41 35 49 69, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: This Research is in accordance with the tenets of the Helsinki Declaration (as revised in 2013), and has been approved by the Bioethical Committee of Angers University Hospital (n° 2015-15).

References

1. Stabler, SP. Vitamin B12 deficiency. N Engl J Med 2013;368:149–60. https://doi.org/10.1056/nejmcp1113996.Search in Google Scholar PubMed

2. Carmel, R. How I treat cobalamin (vitamin B12) deficiency. Blood 2008;112:2214–21. https://doi.org/10.1182/blood-2008-03-040253.Search in Google Scholar PubMed PubMed Central

3. Fedosov, SN. Biochemical markers of vitamin B12 deficiency combined in one diagnostic parameter: the age-dependence and association with cognitive function and blood hemoglobin. Clin Chim Acta 2013;422:47–53. https://doi.org/10.1016/j.cca.2013.04.002.Search in Google Scholar PubMed

4. Fedosov, SN, Brito, A, Miller, JW, Green, R, Allen, LH. Combined indicator of vitamin B12 status: modification for missing biomarkers and folate status and recommendations for revised cut-points. Clin Chem Lab Med 2015;53:1215–25. https://doi.org/10.1515/cclm-2014-0818.Search in Google Scholar PubMed

5. Loikas, S, Koskinen, P, Irjala, K, Löppönen, M, Isoaho, R, Kivelä, S-L, et al.. Renal impairment compromises the use of total homocysteine and methylmalonic acid but not total vitamin B12 and holotranscobalamin in screening for vitamin B12 deficiency in the aged. Clin Chem Lab Med 2007;45:197–201. https://doi.org/10.1515/cclm.2007.028.Search in Google Scholar PubMed

6. Obeid, R, Herrmann, W. Holotranscobalamin in laboratory diagnosis of cobalamin deficiency compared to total cobalamin and methylmalonic acid. Clin Chem Lab Med 2007;45:1746–50. https://doi.org/10.1515/cclm.2007.361.Search in Google Scholar

7. Supakul, S, Chabrun, F, Genebrier, S, N’Guyen, M, Valarche, G, Derieppe, A, et al.. Diagnostic performances of urinary methylmalonic acid/creatinine ratio in vitamin B12 deficiency. J Clin Med 2020;9:2335. https://doi.org/10.3390/jcm9082335.Search in Google Scholar PubMed PubMed Central

8. Dalmia, A, Dib, M-J, Maude, H, Harrington, DJ, Sobczyńska-Malefora, A, Andrew, T, et al.. A genetic epidemiological study in British adults and older adults shows a high heritability of the combined indicator of vitamin B12 status (cB12) and connects B12 status with utilization of mitochondrial substrates and energy metabolism. J Nutr Biochem 2019;70:156–63. https://doi.org/10.1016/j.jnutbio.2019.04.008.Search in Google Scholar PubMed

9. Akış, M, Kant, M, Işık, İ, Kısa, PT, Köse, E, Arslan, N, et al.. Functional vitamin B12 deficiency in phenylketonuria patients and healthy controls: an evaluation with combined indicator of vitamin B12 status as a biochemical index. Ann Clin Biochem: Internet J Lab Med 2020;57:291–9. https://doi.org/10.1177/0004563220935140.Search in Google Scholar PubMed

10. Hinkel, J, Schmitt, J, Wurm, M, Rosenbaum-Fabian, S, Schwab, KO, Jacobsen, DW, et al.. Elevated plasma vitamin B12 in patients with hepatic glycogen storage diseases. J Clin Med 2020;9:2326. https://doi.org/10.3390/jcm9082326.Search in Google Scholar PubMed PubMed Central

Received: 2020-08-14
Accepted: 2020-10-08
Published Online: 2020-10-19
Published in Print: 2021-03-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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