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Licensed Unlicensed Requires Authentication Published by De Gruyter October 12, 2020

Exogenous triglycerides interfere with a point of care CRP assay: a pre-analytical caveat

  • Nick Verougstraete , Frederick Verbeke and Joris R. Delanghe ORCID logo EMAIL logo

Corresponding author: Prof. Dr. Joris R. Delanghe, Department of Diagnostic Sciences, Ghent University, C. Heymanslaan 10, 9000 Ghent, Belgium, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.


1. Verbakel, JY, Lemiengre, MB, De Burghgraeve, T, De Sutter, A, Aertgeerts, B, Shinkins, B, et al. Should all acutely ill children in primary care be tested with point-of-care CRP: a cluster randomised trial. BMC Med 2016;14:131. in Google Scholar

2. Tugirimana, PL, Holderbeke, AL, Kint, JA, Delanghe, JR. A new turbidimetric method for assaying C-reactive protein based on phosphocholine interaction. Clin Chem Lab Med 2009;47:1417–22. in Google Scholar

3. De Haene, H, Taes, Y, Christophe, A, Delanghe, J. Comparison of triglyceride concentration with lipemic index in disorders of triglyceride and glycerol metabolism. Clin Chem Lab Med 2006;44:220–2. in Google Scholar

4. Abbott. Afinion CRP package insert, 1116908 Rev. A 2019/02.Search in Google Scholar

5. Minnaard, MC, van de Pol, AC, Broekhuizen, BDL, Verheij, TJM, Hopstaken, RM, van Delft, S, et al. Analytical performance, agreement and user-friendliness of five C-reactive protein point-of-care tests. Scand J Clin Lab Invest 2013;73:627–34. in Google Scholar

6. Brouwer, N, van Pelt, J. Validation and evaluation of eight commercially available point of care CRP method. Clin Chim Acta 2015;439:195–201. in Google Scholar

7. Volanakis, JE, Clements, WL, Schrohenloher, RE. C-reactive protein. Purification by affinity chromatography and physicochemical characterization. J Immunol Methods 1978;23:285–95. in Google Scholar

8. Verbeke, F, Lambrecht, S, Lecocq, E, Parez, J, Delanghe, J. Increased C-reactive protein values in the absence of inflammation: monoclonal immunoglobulin interference in immunonephelometry. Clin Chem Lab Med 2019;57:e311–3. in Google Scholar

9. Westgard, QC. Desirable biological variation database specifications. Available from: [Accessed 20 Sep 2020].Search in Google Scholar

10. Cohn, JS, McNamara, JR, Cohn, SD, Ordovas, JM, Schaefer, EJ. Postprandial plasma lipoprotein changes in human subjects of different ages. J Lipid Res 1988;29:469–79.10.1016/S0022-2275(20)38520-5Search in Google Scholar

11. Zöllner, N. Auswirkungen des Ernährungszustands auf klinisch-chemische Parameter. In: Lang, H, Rick, W, Róka, L, editors. Optimierung der Diagnostik. Berlin, Heidelberg: Springer; 1973. pp. 81–90.10.1007/978-3-642-65717-7_8Search in Google Scholar

Received: 2020-08-25
Accepted: 2020-09-28
Published Online: 2020-10-12
Published in Print: 2021-03-26

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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