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Licensed Unlicensed Requires Authentication Published by De Gruyter November 19, 2020

Significant interference on specific point-of-care glucose measurements due to high dose of intravenous vitamin C therapy in critically ill patients

  • Daan ten Berge , Wim Muller , Albertus Beishuizen , Alexander Daniel Cornet , Robbert Slingerland and Johannes Krabbe EMAIL logo

Corresponding author: Johannes Krabbe, Department of Clinical Chemistry and Laboratory Medicine, Medlon BV, Enschede, The Netherlands; and Department of Clinical Chemistry and Laboratory Medicine, Medisch Spectrum Twente, Ariensplein 1, Enschede 7500 KA, The Netherlands, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: Not applicable.


1. Boretti, A, Banik, BK. Intravenous vitamin C for reduction of cytokines storm in acute respiratory distress syndrome. Pharma Nutr 2020. [Epub ahead of print].Search in Google Scholar

2. Marik, PE. Hydrocortisone, ascorbic acid and thiamine (HAT therapy) for the treatment of sepsis. Focus Ascorbic Acid Nutr 2018;10:17623.10.20944/preprints201810.0285.v1Search in Google Scholar

3. Lui, F, Zhu, Y, Zhang, J, Li, Y, Peng, Z. Intravenous high-dose vitamin C for the treatment of severe COVID-19: study protocol for a multicentre randomised controlled trial. BMJ Open 2020;10:e039519, in Google Scholar

4. Peyton Howell, A, Parrett, JL, Malcom, DR. Impact of high-dose intravenous vitamin C for treatment of sepsis on point-of-care blood glucose readings. J Diabetes Sci Technol 2019. [Epub ahead of print].Search in Google Scholar

5. Tang, Z, Du, X, Louie, RF, Kost, GJ. Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer. Am J Clin Pathol 2000;113:75–86, in Google Scholar

6. US Food and Drug Administration. Blood glucose monitoring test systems for prescription point-of-care use guidance for industry and food and drug administration staff. Rockville, MD: US Food and Drug Administration; 2016. Available from: [Accessed 15 Aug 2020].Search in Google Scholar

7. Jansen, RT, Slingerland, RJ. SKML-Quality Mark for point-of-care test (POCT) glucose meters and glucose meters for home-use. Clin Chem Lab Med 2010;48:1021–7, in Google Scholar

8. Schrier, RW, Wang, W. Acute renal failure and sepsis. N Engl J Med 2004;351:159–69, in Google Scholar

9. Ronco, C, Reis, T, Husain-Syed, F. Management of acute kidney injury in patients with COVID-19. Lancet Respir Med 2020;8:738–42, in Google Scholar

10. van Balveren, JA, Verboeket-van de Venne, WPHG, Erdem-Eraslan, L, de Graaf, AJ, Loot, AE, Musson, REA, et al.. Clin Chem Lab Med 2018;56:2004–9, in Google Scholar PubMed

Received: 2020-09-28
Accepted: 2020-11-03
Published Online: 2020-11-19
Published in Print: 2021-04-27

© 2020 Walter de Gruyter GmbH, Berlin/Boston

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