Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter March 15, 2021

Procalcitonin measurement by Diazyme™ immunturbidimetric and Elecsys BRAHMS™ PCT assay on a Roche COBAS modular analyzer

Andreas Jensch , Elisabeth Mahla , Wolfgang Toller , Markus Herrmann and Harald Mangge ORCID logo EMAIL logo

Corresponding author: Dr. Harald Mangge, Univ. Prof., Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Auenbruggerplatz 15, 8036 Graz, Austria, Phone: +43 316 385 83340, Fax: +43 316 385 13430, E-mail:

  1. Research funding: None declared.

  2. Author contributions: Andreas Jensch: Data acquisition, diploma thesis, manuscript preparation. Markus Herrmann: Manuscript conception. Elisabeth Mahla: Clinical consultant. Harald Mangge: Manuscript writing, supervision of the diploma thesis of Andreas Jensch. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval: Not applicable.


1. Müller, B, White, JC, Nylén, ES, Snider, RH, Becker, KL, Habener, JF. Ubiquitous expression of the calcitonin-i gene in multiple tissues in response to sepsis. J Clin Endocrinol Metab 2001;86:396–404. in Google Scholar

2. Linscheid, P, Seboek, D, Schaer, DJ, Zulewski, H, Keller, U, Müller, B. Expression and secretion of procalcitonin and calcitonin gene-related peptide by adherent monocytes and by macrophage-activated adipocytes. Crit Care Med 2004;32:1715–21. in Google Scholar

3. Wiedermann, FJ, Kaneider, N, Egger, P, Tiefenthaler, W, Wiedermann, CJ, Lindner, KH, et al.. Migration of human monocytes in response to procalcitonin. Crit Care Med 2002;30:1112–7. in Google Scholar

4. Hoffmann, G, Czechowski, M, Schloesser, M, Schobersberger, W. Procalcitonin amplifies inducible nitric oxide synthase gene expression and nitric oxide production in vascular smooth muscle cells. Crit Care Med 2002;30:2091–5. in Google Scholar

5. Meisner, M. Update on procalcitonin measurements. Ann Lab Med 2014;34:263–73. in Google Scholar

6. Hohn, A, Schroeder, S, Gehrt, A, Bernhardt, K, Bein, B, Wegscheider, K, et al.. Procalcitonin-guided algorithm to reduce length of antibiotic therapy in patients with severe sepsis and septic shock. BMC Infect Dis 2013;13:158. in Google Scholar

7. Lippi, G, Salvagno, GL, Gelati, M, Pucci, M, Lo Cascio, C, Demonte, D, et al.. Two-center comparison of 10 fully-automated commercial procalcitonin (PCT) immunoassays. Clin Chem Lab Med 2019;58:77–84. in Google Scholar

8. Dipalo, M, Guido, L, Micca, G, Pittalis, S, Locatelli, M, Motta, A, et al.. Multicenter comparison of automated procalcitonin immunoassays. Pract Lab Med 2015;2:22–8. in Google Scholar

9. Ceriotti, F, Marino, I, Motta, A, Carobene, A. Analytical evaluation of the performances of Diazyme and BRAHMS procalcitonin applied to Roche Cobas in comparison with BRAHMS PCT-sensitive Kryptor. Clin Chem Lab Med 2017;56:162–9. in Google Scholar

10. Dipalo, M, Buonocore, R, Gnocchi, C, Picanza, A, Aloe, R, Lippi, G. Analytical evaluation of Diazyme procalcitonin (PCT) latex-enhanced immunoturbidimetric assay on Beckman Coulter AU5800. Clin Chem Lab Med 2015;53:593–7. in Google Scholar

Received: 2020-09-28
Accepted: 2021-02-25
Published Online: 2021-03-15
Published in Print: 2021-08-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 30.1.2023 from
Scroll Up Arrow