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Licensed Unlicensed Requires Authentication Published by De Gruyter February 10, 2021

Influence of C-reactive protein on thrombin generation assay

Marie Didembourg ORCID logo, Jonathan Douxfils ORCID logo, François Mullier, Michael Hardy, Julien Favresse and Laure Morimont ORCID logo

Corresponding author: Laure Morimont, Faculty of Medicine, Department of Pharmacy, Namur Thrombosis and Hemostasis Center (NTHC), Namur Research Institute for Life Sciences (NARILIS), University of Namur, Namur, Belgium; and QUALIblood SA, Rue du Séminaire 20a, 5000Namur, Belgium, Phone: +32 81 444 992, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Among the authors, J. Douxfils is CEO and founder of QUALIblood s.a., a contract research organization manufacturing the DP-Filter, is co-inventor of the DP-Filter (patent application number: PCT/ET2019/052903) and reports personal fees from Daiichi-Sankyo, Mithra Pharmaceuticals, Stago, Roche and Roche Diagnostics outside the submitted work. F. Mullier reports institutional fees from Stago, Werfen, Nodia, Roche Sysmex and Bayer. He also reports speaker fees from Boehringer Ingelheim, Bayer Healthcare, Bristol-MyersSquibb-Pfizer, Stago, Sysmex and Aspen all outside the submitted work. The other authors have no conflicts of interest to disclose.

  4. Ethical approval: Recruitment of healthy volunteers for the constitution of a normal pooled plasma (NPP) has been approved by the Ethical Committee of the CHU-UCL Namur, Yvoir, Belgium (approval number: B03920096633).


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Received: 2020-11-10
Accepted: 2021-01-29
Published Online: 2021-02-10
Published in Print: 2021-06-25

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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