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Licensed Unlicensed Requires Authentication Published by De Gruyter September 15, 2021

Cerebrospinal fluid neurogranin in Alzheimer’s disease studies: are immunoassay results interchangeable?

  • Clément Aveneau , Claire Hourregue , Emmanuel Cognat , Julien Dumurgier , Hugo Vanderstichele , Eugeen Vanmechelen , Henrik Zetterberg , Jacques Hugon , Kaj Blennow , Claire Paquet EMAIL logo and Elodie Bouaziz-Amar

Corresponding author: Prof. Claire Paquet, Center of Cognitive Neurology/Research Memory Center Paris Nord, GHU AP-HP Nord, Lariboisière-Fernand Widal Hospital, 200 rue du Faubourg Saint-Denis, 75010, Paris, France, Phone: +33 140054954, Fax: +33 140054339, E-mail:

Claire Paquet and Elodie Bouaziz-Amar contributed equally to this work.

Funding source: Fondation Pagnol

Funding source: Fondation Philippe Chatrier

Funding source: Stiftelsen för Gamla Tjänarinnor, Demensfonden, Stiftelsen Sigurd och Elsa Golje

Funding source: The Swedish Alzheimer Foundation

Funding source: The Swedish Brain Foundation


All patients signed an informed consent, and this study was approved by the Bichat hospital ethics committee of Paris Diderot University.

  1. Research funding: This study was supported jointly by the Fondation Philippe Chatrier (Paris, France), Fondation Plagnol, Fondation Vaincre Alzheimer (Paris, France), The Swedish Alzheimer Foundation, The Swedish Brain Foundation, Stiftelsen för Gamla Tjänarinnor, Demensfonden, Stiftelsen Sigurd och Elsa Golje, Torsten Söderberg Foundation, the European Research Council and the Knut and Alice Wallenberg Foundation. CSF ELISA kit neurogranin assays were provided by ADX Neurosciences.

  2. Author contributions: All the authors have accepted responsibility for the entire content of this submitted manuscript and approved submission.

  3. Competing interests: Mr AVENEAU (medical resident) declare no disclosure. Dr COGNAT and Dr DUMURGIER are investigator in several passive anti-amyloid immunotherapies and other clinical trials for Roche, Eisai, Lilly, Biogen, Astra-Zeneca, Lundbeck. Dr BOUAZIZ-AMAR is member of the National Advisory Board of Roche. Prof. ZETTERBERG has served at scientific advisory boards for Roche Diagnostics, Wave, Samumed and CogRx, has given open lectures sponsored by Alzecure, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Ventures-based platform company at the University of Gothenburg. Prof. HUGON is investigator in several passive anti-amyloid immunotherapies and other clinical trials for Roche, Eisai, Lilly, Biogen, Astra-Zeneca, Lundbeck. He is a member of the advisory boards of RAMAN Health, Roche and Lilly. Prof. PAQUET is member of the International Advisory Boards of Lilly, is consultant of Fujiribio, ALZOHIS, NEUROIMMUNE, Ads Neuroscience, Roche, AgenT and GILEAD and is involved as investigator in several clinical trials for Roche, Esai, Lilly, Biogen, Astra-Zeneca, Lundbeck, Neuroimmune. Prof. BLENNOW has served as a consultant or at advisory boards for Alzheon, BioArctic, Biogen, Eli Lilly, Fujirebio Europe, IBL International, Merck, Novartis, Pfizer, and Roche Diagnostics, and is a co-founder of Brain Biomarker Solutions in Gothenburg AB, a GU Venture-based platform company at the University of Gothenburg. HV et EM were employees of ADx neurosciences at the period of the assessments.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The study was approved by the local Ethics Committee.


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Supplementary Material

The online version of this article offers supplementary material (

Received: 2021-05-13
Accepted: 2021-08-12
Published Online: 2021-09-15
Published in Print: 2022-01-26

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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