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Licensed Unlicensed Requires Authentication Published by De Gruyter October 19, 2021

Troponin interference with special regard to macrocomplex formation

Bernhard Strasser ORCID logo, Josef Tomasits, Alexander Fellner and Thomas Lambert


Biomarkers, such as troponin-T and troponin-I, are regarded as the gold standard laboratory parameter for diagnosing many cardiological diseases. These parameters have been approved for clinical use. Many cardiological guidelines recommend the analysis of troponins in the majority of cardiological disease diagnoses and to also gain prognostic information. Nonetheless, many medical circumstances could cause false troponin elevations. In this article, we focus on troponin artifacts, particularly macro-immune complex formation, as important interference factors. Therefore, we performed a literature search from 2006 to 06/2021.

Corresponding author: Dr. Bernhard Strasser, Institute of Laboratory Medicine, Kepler University Hospital Linz, Krankenhausstr. 26–30, 4020 Linz, Austria, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Received: 2021-07-27
Accepted: 2021-10-06
Published Online: 2021-10-19
Published in Print: 2022-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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