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Licensed Unlicensed Requires Authentication Published by De Gruyter October 22, 2021

Value of hypocalcemia and thromboinflammatory biomarkers for prediction of COVID-19 severity during the second wave: were all the waves the same?

Luis García de Guadiana-Romualdo ORCID logo EMAIL logo , Verónica Ramos-Arenas , María Dolores Rodríguez Mulero , Marta Hernández Olivo , Valerio Campos-Rodríguez , María Galindo Martínez , María Salomé Ros Braquehais , Luciano Consuegra-Sánchez , Mercedes González Morales and María Dolores Albaladejo-Otón

Corresponding author: Luis García de Guadiana-Romualdo, Laboratory Medicine Department, Hospital Universitario Santa Lucía, Calle Mezquita s/n, Paraje Los Arcos, CP 30202, Cartagena, Spain, E-mail:

  1. Research funding: None declared.

  2. Author contributions: LGGR designed the study, analyzed the data and wrote the manuscript. LCS provided statistical advice. VRA, MGM and MDAO collected the laboratory investigations. MDRM, MHO, MGM, MSRB and VCR contributed to the enrolment of patients and clinical data collection. All authors have reviewed critically the manuscript and have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Ethical approval and informed consent: The study was approved by the local Ethics Committee (E.O.2020-38 LAB2-COVID19) and performed under a waiver of informed consent and in accordance with the Declaration of Helsinki ethical guidelines.


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Received: 2021-09-09
Accepted: 2021-10-11
Published Online: 2021-10-22
Published in Print: 2022-01-27

© 2021 Walter de Gruyter GmbH, Berlin/Boston

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