Skip to content
Licensed Unlicensed Requires Authentication Published by De Gruyter January 26, 2022

Rare unstable and low oxygen affinity haemoglobin variant, Hb Hazebrouck, detected on Sysmex XN-9000

  • Anne-Sophie Adam ORCID logo EMAIL logo , Sara Benyaich , Martin Colard , Fleur Samantha Benghiat , Frédéric Cotton and Béatrice Gulbis

Corresponding author: Anne-Sophie Adam, Department of Clinical Chemistry, LHUB-ULB, Université Libre de Bruxelles, Rue Haute 322, 1000 Brussels, Belgium, Phone: +32 2 435 25 71, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The local Institutional Review Board deemed the study exempt from review.


1. Giardine, BM, Joly, P, Pissard, S, Wajcman, H, Chui, DHK, Hardison, RC, et al.. Clinically relevant updates of the HbVar database of human hemoglobin variants and thalassemia mutations. Nucleic Acids Res 2021;49:D1192–6. in Google Scholar

2. Gallagher, PG. Diagnosis and management of rare congenital nonimmune hemolytic disease. Hematology Am Soc Hematol Educ Program 2015;2015:392–9. in Google Scholar

3. Zinkham, WH, Winslow, RM. Unstable hemoglobins: influence of environment on phenotypic expression of a genetic disorder. Medicine (Baltim) 1989;68:309–20. in Google Scholar

4. Jongbloed, W, van Twillert, G, Schoorl, M, Schindhelm, RK. Unstable haemoglobin variant Hb Leiden is detected on Sysmex XN-Series analysers. Clin Chem Lab Med 2018;56:e249–50. in Google Scholar

5. Mongelli, F, Barberio, G, Ivaldi, G. A rare and unstable hemoglobin variant, Hb M Dothan β 25/26 (-GTG), detected by the anomalous cytogram on Sysmex XE-2100. Clin Chem Lab Med 2016;54:e31–3. in Google Scholar

6. Rosetti, M, Poletti, G, Sensi, A, Ravani, A, Rondoni, M, Baldrati, L, et al.. A rare case of Hemoglobin Leiden interfering with the DIFF channel of Sysmex XE-2100. Scand J Clin Lab Invest 2015;75:436–7. in Google Scholar

7. Teixeira, C, Pina, D, Freitas, MI. Automated detection of unstable hemoglobin variants by Sysmex XE-Series analyzers. Clin Chem Lab Med 2017;55:e243–6. in Google Scholar

8. Blouquit, Y, Delanoe-Garin, J, Lacombe, C, Arous, N, Cayre, Y, Peduzzi, J, et al.. Structural study of hemoglobin Hazebrouck, beta 38(C4)Thr→Pro. A new abnormal hemoglobin with instability and low oxygen affinity. FEBS Lett 1984;172:155–8. in Google Scholar

Received: 2021-12-16
Accepted: 2022-01-17
Published Online: 2022-01-26
Published in Print: 2022-04-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

Downloaded on 24.9.2023 from
Scroll to top button