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Licensed Unlicensed Requires Authentication Published by De Gruyter February 18, 2022

Added value of drug-laboratory test interaction alerts in test result authorisation

Jasmijn A. van Balveren, Wilhelmine P.H.G. Verboeket-van de Venne, Carine J.M. Doggen, Lale Erdem-Eraslan, Albert J. de Graaf, Johannes G. Krabbe, Ruben E.A. Musson, Wytze P. Oosterhuis, Yolanda B. de Rijke, Heleen van der Sijs, Andrei N. Tintu, Rolf J. Verheul, Rein M.J. Hoedemakers and Ron Kusters

Corresponding author: Jasmijn A. van Balveren, MSc, Laboratory for Clinical Chemistry and Haematology, Jeroen Bosch Hospital, Henri Dunantstraat 1, PO box 90153, ’s-Hertogenbosch, The Netherlands; and Department of Health Technology and Services Research, Technical Medical Centre, University of Twente, Enschede, The Netherlands, Phone: +31 (0)73 553 27 64, Fax: +31 (0)73 5532958, E-mail:

Funding source: Stichting Kwaliteitsgelden Medisch Specialisten

Award Identifier / Grant number: 42678870

  1. Research funding: This study received funding from Stichting Kwaliteitsgelden Medisch Specialisten (SKMS), grant number 42678870.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: The Dutch Medical Research involving Human Subjects Act (WMO) did not apply to this study.

References

1. Whiting, PF, Davenport, C, Jameson, C, Burke, M, Sterne, JA, Hyde, C, et al.. How well do health professionals interpret diagnostic information? A systematic review. BMJ Open 2015;5:1–13. https://doi.org/10.1136/bmjopen-2015-008155.Search in Google Scholar

2. Vlasveld, LT, van’t Wout, J, Castel, A. False elevation of chromogranin A due to proton pump inhibitors. Neth J Med 2011;69:207.Search in Google Scholar

3. Tang, F, Malek, E, Math, S, Schmotzer, CL, Beck, RC. Interference of therapeutic monoclonal antibodies with routine serum protein electrophoresis and immunofixation in patients with myeloma. Am J Clin Pathol 2018;150:121–9. https://doi.org/10.1093/ajcp/aqy037.Search in Google Scholar

4. Young, D. Effects of drugs on clinical laboratory tests. Washington: AACC Press; 2000.Search in Google Scholar

5. van Balveren, JA, Verboeket-van de Venne, W, Erdem-Eraslan, L, de Graaf, AJ, Loot, AE, Musson, REA, et al.. Impact of interactions between drugs and laboratory test results on diagnostic test interpretation - a systematic review. Clin Chem Lab Med 2018;56:2004–9. https://doi.org/10.1515/cclm-2018-0900.Search in Google Scholar

6. van Balveren, JA, Verboeket, WPHG, Cornelissen, AS, Doggen, CJM, Erdem, L, de Graaf, AJ, et al.. Clinical usefulness of drug-laboratory test interaction alerts: a multicentre survey. Clin Chem Lab Med 2021;59:1239–45. https://doi.org/10.1515/cclm-2020-1770.Search in Google Scholar

7. Bates, DW, Kuperman, GJ, Wang, S, Gandhi, T, Kittler, A, Volk, L, et al.. Ten commandments for effective clinical decision support: making the practice of evidence-based medicine a reality. J Am Med Inf Assoc 2003;10:523–30. https://doi.org/10.1197/jamia.m1370.Search in Google Scholar

8. van Balveren, JA, Verboeket, WPHG, Doggen, CJM, Erdem, L, de Graaf, AJ, Krabbe, JG, et al.. Real-time monitoring of drug laboratory test interactions: a proof of concept. Clin Chem Lab Med 2021;60:235–242. https://doi.org/10.1515/cclm-2021-0790.Search in Google Scholar

9. Oosterhuis, WP. Adding clinical utility to the laboratory reports: automation of interpretative comments. Clin Chem Lab Med 2019;57:365–70. https://doi.org/10.1515/cclm-2018-0623.Search in Google Scholar

Received: 2021-11-04
Accepted: 2022-01-31
Published Online: 2022-02-18
Published in Print: 2022-04-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston