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Licensed Unlicensed Requires Authentication Published by De Gruyter February 22, 2022

Lot-to-lot reagent verification: challenges and possible solutions

Tze Ping Loh, Sverre Sandberg and Andrea Rita Horvath


Lot-to-lot verification is an important laboratory activity that is performed to monitor the consistency of analytical performance over time. In this opinion paper, the concept, clinical impact, challenges and potential solutions for lot-to-lot verification are exained.

Corresponding author: Tze Ping Loh, Department of Laboratory Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074, Singapore, Phone: (+65) 67724345, Fax: (+65) 67771613, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Received: 2022-02-03
Accepted: 2022-02-09
Published Online: 2022-02-22
Published in Print: 2022-04-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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