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Licensed Unlicensed Requires Authentication Published by De Gruyter March 14, 2022

Clearance of macro-TSH from the circulation is slower than TSH

  • Ayato Yamada , Naoki Hattori EMAIL logo , Takeshi Matsuda , Norito Nishiyama and Akira Shimatsu

Corresponding author: Naoki Hattori, MD, PhD, Department of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Nojihigashi, Kusatsu-city, Shiga 525-8577, Japan, E-mail:


We thank Geoff Gillespie for his assistance in preparing this manuscript.

  1. Research funding: This work was supported by the grant from Ritsumeikan University.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: All animal experimental procedures and protocols were approved by the Institutional Animal Care and Ethics Committee of Ritsumeikan University (BKC2020-005).


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Received: 2022-02-15
Accepted: 2022-03-04
Published Online: 2022-03-14
Published in Print: 2022-05-25

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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