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Licensed Unlicensed Requires Authentication Published by De Gruyter June 10, 2022

Hypertriglyceridemia, a causal risk factor for atherosclerosis, and its laboratory assessment

  • Ewa Wieczorek ORCID logo EMAIL logo , Agnieszka Ćwiklińska and Maciej Jankowski


Epidemiological and clinical studies show a causal association between serum triglyceride (TG) level, the number of triglyceride-rich lipoproteins (TRLs) and their remnants, and the increased risk of atherosclerosis and cardiovascular disease (CVD) development. In light of current guidelines for dyslipidemia management, the laboratory parameters reflecting TRL content are recommended as part of the routine lipid analysis process and used for CVD risk assessment, especially in people with hypertriglyceridemia (HTG), diabetes mellitus, obesity and low levels of low-density lipoprotein cholesterol (LDL-C), in which high residual CVD risk is observed. The basic routinely available laboratory parameters related with TRL are serum TG and non-high-density lipoprotein cholesterol (non-HDL-C) levels, but there are also other biomarkers related to TRL metabolism, the determination of which can be helpful in identifying the basis of HTG development or assessing CVD risk or can be the target of pharmacological intervention. In this review, we present the currently available laboratory parameters related to HTG. We summarise their link with TRL metabolism and HTG development, the determination methods as well as their clinical significance, the target values and interpretation of the results in relation to the current dyslipidemia guidelines.

Corresponding author: Ewa Wieczorek, MSc, Department of Clinical Chemistry, Medical University of Gdańsk, Dębinki 7 Street, 80-211 Gdańsk, Poland, Phone: +48 583492777, E-mail:


Not applicable.

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Received: 2022-03-02
Accepted: 2022-04-29
Published Online: 2022-06-10
Published in Print: 2022-07-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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