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Licensed Unlicensed Requires Authentication Published by De Gruyter June 22, 2022

The predictive value of hemoglobin to creatinine ratio for contrast-induced nephropathy in percutaneous coronary interventions

  • Sencer Çamci , Mustafa Kinik , Selma Ari , Hasan Ari EMAIL logo , Mehmet Melek and Tahsin Bozat



Hemoglobin and creatinine levels are important factors for contrast induced nephropathy (CIN) development. Our aim in this study is to investigate the predictive value of hemoglobin to creatinine ratio for CIN development in patients with percutaneous coronary intervention (PCI).


A total of 500 patients who underwent PCI in our clinic were evaluated prospectively in terms of CIN. Hemoglobin to creatinine ratio is calculated as baseline hemoglobin/baseline serum creatinine value. glomerular filtration rate (GFR) was calculated with Cockcroft-Gault formula. The definition of CIN includes absolute (≥0.5 mg/dL) or relative increase (≥25%) in serum creatinine at 48–72 h after exposure to a contrast agent compared to baseline serum creatinine values.


CIN was detected in 13.8% (69 patients) of 500 patients. In multivariate lineer regression analysis, hemoglobin to creatinine ratio (beta: −0.227, p=0.03) and ejection fraction (EF) (beta: −0.161, p<0.001), contrast amount used (beta: 0.231, p<0.001) were found to be significant predictors for the development of CIN. In receiver operating characteristics (ROC) analysis; AUC=0.730 (0.66–0.79) for hemoglobin to creatinine ratio, p<0.001, AUC=0.694 (0.62–0.76) for EF, p<0.001 and AUC=0.731 (0.67–0.78) for contrast amount used p<0.001.


Hemoglobin to creatinine ratio, EF and contrast amount used were independent predictors for CIN development in patients with PCI (NCT04703049).

Corresponding author: Dr. Hasan Ari, Professor, MD, Department of Cardiology, Bursa Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, Bursa, Turkey, Phone: 02243605050, Fax: 02243605055, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The approval of the hospital Ethics Committee (Bursa Postgraduate Hospital Ethics Committee) was obtained for the study.


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Received: 2022-03-04
Accepted: 2022-06-03
Published Online: 2022-06-22
Published in Print: 2022-08-26

© 2022 Walter de Gruyter GmbH, Berlin/Boston

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