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Licensed Unlicensed Requires Authentication Published by De Gruyter January 13, 2023

Proenkephalin A 119–159 (penKid) – a novel biomarker and its quantification on the Nexus IB10 POC system for assessing kidney function

  • Jared Cobb , Karolina Szczesna , Axel Schulze , Huy Ngo , McKenna Doyle , Tyler Do , Minh Vu , John Nguyen , Julia Löffler , Maryna Borshchivska , Deborah Bergmann , Elizabeth Shin , Tobias Hartmann and Damien Gruson EMAIL logo

Corresponding author: Prof. Damien Gruson, Department of Clinical Biochemistry, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium; and Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc and Université Catholique de Louvain, Brussels, Belgium, E-mail:
Jared Cobb and Karolina Szczesna contributed equally to this work.
  1. Research funding: None declared.

  2. Author contributions: Jared Cobb, Karolina Szczesna and others at Nexus Dx performed experimental design, conducted the experiments, analyzed and interpreted the results. Jared Cobb and Karolina Szczesna wrote the manuscript. Jared Cobb and Axel Schulze performed data analyses. Karolina Szczesna and Julia Löffler helped with data analyses. Deborah Bergmann was involved in the experimental design and read and approved the final version of the paper. Elizabeth Shin was involved experimental design, and approved the final version. Tobias Hartmann helped with experimental design and implementation of experiments, read and approved the final version of the paper. Damien Gruson and others at CUSL helped with analyses and interpretation of the results, and approved the final version.

  3. Competing interests: The authors confirm that this paper content has no conflict of interests. Jared Cobb, Tyler Do, Minh Vu, John Nguyen and Elizabeth Shin are currently employed by Nexus Dx. Karolina Szczesna, Axel Schulze, Deborah Bergmann and Tobias Hartmann are employed by SphingoTec GmbH, Hennigsdorf (Berlin), Germany. Huy Ngo and McKenna Doyle are an ex-employee of Nexus-Dx, San Diego, CA, USA. Julia Löffler is a former employee of SphingoTec GmbH, Hennigsdorf (Berlin), Germany. The here presented work was performed during the employment.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


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Supplementary Material

This article contains supplementary material (

Received: 2022-11-21
Accepted: 2022-12-23
Published Online: 2023-01-13
Published in Print: 2023-06-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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