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Licensed Unlicensed Requires Authentication Published by De Gruyter January 31, 2023

Falsely low beta-hCG results in pregnant woman on Siemens Atellica: don’t forget the “hook effect”

  • Adrien Nizet EMAIL logo , Philippe Jeanmart , Lucas Dewalque and Quentin Bodson

Corresponding author: Adrien Nizet, Department of Laboratory Medicine, Clinique CHC MontLégia, Liège, Belgium, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


1. Nodler, JL, Kim, KH, Alvarez, RD. Abnormally low hCG in a complete hydatidiform molar pregnancy: the hook effect. Gynecol Oncol Case Rep 2011;1:6–7. in Google Scholar PubMed PubMed Central

2. Al-Mahdili, HA, Jones, GRD. High-dose hook effect in six automated human chorionic gonadotrophin assays. Ann Clin Biochem Int J Lab Med 2010;47:383–5.10.1258/acb.2010.090304Search in Google Scholar PubMed

3. Winder, AD, Mora, AS, Berry, E, Lurain, JR. The “hook effect” causing a negative pregnancy test in a patient with an advanced molar pregnancy. Gynecol Oncol Rep 2017;21:34–6.10.1016/j.gore.2017.06.008Search in Google Scholar PubMed PubMed Central

Received: 2022-11-25
Accepted: 2023-01-18
Published Online: 2023-01-31
Published in Print: 2023-06-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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