Research funding: None declared.
Author contributions: CO and AS designed the study. AS and AC carried out assays. CO and BP analysed and interpreted the data. CO wrote the initial version of the manuscript. DB and VS assisted with the interpretation of the data and writing of the manuscript. BP provided statistical advice for the study design. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.
Competing interests: Authors have not conflict of interest.
Informed consent: Not applicable.
Ethical approval: Not applicable.
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