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Licensed Unlicensed Requires Authentication Published by De Gruyter January 24, 2023

Stability of plasma renin concentration based on plasma freezing time, as an adjunct to the stability data reported in the paper by Hepburn and others

  • Charlotte Oris , Damien Bouvier , Bruno Pereira , Adèle Saintonge , Anaïs Coelho and Vincent Sapin ORCID logo EMAIL logo

Corresponding author: Vincent Sapin, PharmD, PhD, Biochemistry and Molecular Genetics Department, University Hospital, Clermont-Ferrand, France; Clermont Auvergne University, CNRS, INSERM, iGReD, Clermont-Ferrand, France; and Service de Biochimie et Génétique Moléculaire, Centre de Biologie, CHU Gabriel Montpied, 58 Rue Montalembert, 63000 Clermont-Ferrand, France, Phone: + 33 4 73 75 18 01, E-mail:

  1. Research funding: None declared.

  2. Author contributions: CO and AS designed the study. AS and AC carried out assays. CO and BP analysed and interpreted the data. CO wrote the initial version of the manuscript. DB and VS assisted with the interpretation of the data and writing of the manuscript. BP provided statistical advice for the study design. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors have not conflict of interest.

  4. Informed consent: Not applicable.

  5. Ethical approval: Not applicable.


1. Burdman, I, Burckhardt, BB. Prorenin and active renin levels in paediatrics: a bioanalytical review. Clin Chem Lab Med 2020;59:275–85. in Google Scholar PubMed

2. Deinum, J, Derkx, FH, Schalekamp, MA. Improved immunoradiometric assay for plasma renin. Clin Chem 1999;45:847–54. in Google Scholar

3. Fyhrquist, F, Puutula, L. Effect of temperature on plasma renin samples. Clin Chem 1978;24:1202–4. in Google Scholar

4. Funder, JW, Carey, RM, Fardella, C, Gomez-Sanchez, CE, Mantero, F, Stowasser, M, et al.. Case detection, diagnosis, and treatment of patients with primary aldosteronism: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 2008;93:3266–81. in Google Scholar PubMed

5. Hepburn, S, Munday, C, Taylor, K, Halsall, DJ. Stability of direct renin concentration and plasma renin activity in EDTA whole blood and plasma at ambient and refrigerated temperatures from 0 to 72 hours. Clin Chem Lab Med 2022;60:1384–92. in Google Scholar PubMed

Received: 2022-12-24
Accepted: 2023-01-11
Published Online: 2023-01-24
Published in Print: 2023-06-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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