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Licensed Unlicensed Requires Authentication Published by De Gruyter June 21, 2023

Bilirubin color interference on prothrombin time and activated partial thromboplastin time tests assessed in patients with liver disease

  • Erica Scalambrino , Elena M. Faioni , Marigrazia Clerici , Ilaria Avarello , Marco Capecchi , Samantha Pasca and Armando Tripodi EMAIL logo

Corresponding author: Armando Tripodi, IRCCS Ca’ Granda Maggiore Hospital Foundation, Angelo Bianchi Bonomi Hemophilia and Thrombosis Center, Milan, Italy; and Fondazione Luigi Villa, Via Pace 9, 20122 Milan, Italy, Phone: +39 0255035437, E-mail:


The study was partially supported by the Italian Ministry of Health – Bando Ricerca Corrente 2022.

  1. Research funding: None declared.

  2. Author contribution: AT conceived the study and wrote the manuscript. ES and MC made laboratory testing, data analysis, and reviewed results. IA, EMF and MC selected patients and reviewed results. SP reviewed results and helped preparing the manuscript. FP reviewed results. All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: The local Institutional Review Board exempted the protocol from review.


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Received: 2023-04-07
Accepted: 2023-05-19
Published Online: 2023-06-21
Published in Print: 2023-11-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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