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Licensed Unlicensed Requires Authentication Published by De Gruyter June 21, 2023

Thrombocytopenia and hyperinflammation are induced by extracellular histones circulating in blood

  • Rosaria Vincenza Giglio , Daniela Ligi ORCID logo , Chiara Della Franca , Bruna Lo Sasso , Julia Zulema Rivas , Luisa Agnello , Ferdinando Mannello ORCID logo EMAIL logo and Marcello Ciaccio

Corresponding author: Ferdinando Mannello, Full Professor, Department of Biomolecular Sciences – DISB, Unit of Clinical Biochemistry, Section of Biochemistry and Biotechnology, University of Urbino Carlo Bo, Via A. Saffi, 2, 61029 Urbino, Italy, E-mail:
Rosaria Vincenza Giglio and Daniela Ligi contributed equally to this work as first authors. Ferdinando Mannello and Marcello Ciaccio contributed equally to this work as senior authors.
  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: This study was approved by the Ethical Committee of University of Palermo (protocol: 07/2019). This work uses data obtained by healthy volunteer subjects (research staff and volunteer medical students) collected at the Dept of BiND and DISB, University of Palermo and Urbino, respectively, as part of their care and healthy bio-humoral checks. All investigations have been conducted according to the Declaration of Helsinki principles. In line with non-interventional retrospective design of this in vitro study, investigations were performed on volunteers without clinical indications and no clinical decisions were made based on measured values.


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Supplementary Material

This article contains supplementary material (

Received: 2023-06-06
Accepted: 2023-06-06
Published Online: 2023-06-21
Published in Print: 2023-11-27

© 2023 Walter de Gruyter GmbH, Berlin/Boston

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