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Licensed Unlicensed Requires Authentication Published by De Gruyter October 25, 2011

Do genome-wide association scans have potential for translation?

Margarida C. Lopes, Eleftheria Zeggini and Kalliope Panoutsopoulou


The success of genome-wide association studies (GWAS) in identifying replicating associations has greatly contributed to understanding of the genetic aetiology of complex diseases. This review discusses and provides examples of the potential of GWAS findings to be translated into clinical practice, i.e., diagnosis, prediction, prognosis, novel treatments and response to treatment of common diseases. The biological insights afforded by newly-identified robust associations represent the largest, albeit indirect, translational contribution of GWAS.

Corresponding author: Dr. Eleftheria Zeggini, Wellcome Trust Sanger Institute, The Morgan Building, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1HH, UK Phone: +44 1223 496868, Fax: +44 1223 496826

Received: 2011-4-7
Accepted: 2011-9-17
Published Online: 2011-10-25
Published in Print: 2012-02-01

©2012 by Walter de Gruyter Berlin Boston

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