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BY-NC-ND 4.0 license Open Access Published by De Gruyter September 7, 2017

Labbag® - a versatile bag-based cultivation system for expansion, differentiation and cryopreservation of human stem cells

  • Michael M. Gepp , Rowena Duckstein , Fabian Kayatz , Norbert Rodler , Zuzana Scheuerer , Julia C. Neubauer , Kristina Lachmann , Cornelia Stramm , Andrea Liebmann , Michael Thomas and Heiko Zimmermann EMAIL logo

Abstract

Novel approaches in regenerative medicine and tissue engineering are highly promoted by human induced pluripotent stem cells. Typical workflows include the expansion, differentiation and/or cryopreservation of these cells. Often, the differentiation, cytotoxicity tests or disease modelling rely on multicellular aggregates. Here, we present the novel bag-based system “Labbag®” to address workflows required for these applications. As a unique feature, the Labbag® provides a chemical spot pattern to allow the formation of several hundreds of hanging droplets within a few seconds with standard laboratory equipment. In this study, we describe the general concept of the Labbag® and show aggregate formation of stem cells as first stem cell workflow successfully transferred.

Published Online: 2017-09-07

©2017 Michael M. Gepp et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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