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BY-NC-ND 4.0 license Open Access Published by De Gruyter September 7, 2017

Promising biocompatible hydrogels of crosslinked polyelectrolytes for biomedical applications

  • Andreas Brietzke EMAIL logo , Christian von der Ehe , Sabine Illner , Claudia Matschegewski , Niels Grabow and Udo Kragl

Abstract

For the development of intelligent implant systems hydrogels (HG) from crosslinked ionic liquids feature a high potential to be utilised as a drug depot. Biocompatibility of the HGs is one key prerequisite for biomedical applications. HGs were polymerised from a variety of different ionic monomers based on methacrylate, methacrylamide, styrene or vinyl imidazolium derivatives in aqueous solution. N,N'-methylenebisacrylamide was used as crosslinker. CellQuanti-Blue™ Cell Viability Assay Kit was implemented to proof viability of L929 mouse fibroblasts. The predominant part of the HG eluates generated only a marginal reduction of less than 15% cell viability at 100% eluate concentration. This underlines the excellent suitability of these HGs for biomedical applications and revealed some promising candidates for the development of drug depots for implants.

Published Online: 2017-09-07

©2017 Andreas Brietzke et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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