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BY-NC-ND 4.0 license Open Access Published by De Gruyter September 22, 2018

Inkjet printing for localized coating and functionalization of medical devices

  • Robert Mau EMAIL logo , Gerrit Paasche , Thomas Lenarz and Hermann Seitz

Abstract

Inkjet printing has become essential for pharmaceutical research as well as biomedical applications. It is a promising tool to meet future challenges in patientindividual designed pharmaceuticals and implants. In this context, the main areas of use are high-throughput screening (HTS), drug-loaded microparticles, drug formulation and oral dose development, 3D-printing/bioprinting as well as coating of implants. This study deals with the latter. In view of promising applications for localized coating and functionalization of implant surfaces this work shows preliminary results on inkjet printing of the polymer poly(2- ethyl-2-oxazoline) (PetOx), a protein repellent polymer (PRP). To deposit single droplets with small volumes (~500 pl) of aqueous PetOx solution (50 g/l), printing parameters were determined for the piezo-driven drop-ondemand inkjet printhead NanoTip J, operating in a Nanoplotter 2.1 (both from GeSiM mbH, Germany). Different printing strategies are demonstrated by varying droplet spacing and drying time while printing on hydrophilic glass substrate. Printing and stacking of almost uniform polymer lines (width ~ 200 μm) is demonstrated.

Published Online: 2018-09-22
Published in Print: 2018-09-01

© 2018 the author(s), published by Walter de Gruyter Berlin/Boston

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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