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BY-NC-ND 4.0 license Open Access Published by De Gruyter September 22, 2018

Increased baroreceptor sensitivity in a patient with hereditary spastic paraplegia – type SPG11

  • Gerald Fischer EMAIL logo , Sara Baumgartner Sigl , Daniel Baumgarten and Jürgen Fortin


An 18 years old male patient was diagnosed with genetically confirmed hereditary spastic paraplegia of type SPG11 - a rare disease of neurodegeneration. During normal clinical routine investigation, he presented with a moderate sinus bradycardia. The function of the cardiovascular system was investigated by recording electrocardiogram, impedance cardiogram and continuous blood pressure non-invasively. Cardiac function appeared normal in all modalities. Baroreflex sensitivity was strongly increased by a factor of 2.8. Results indicate that further to hyperactivity of deep tendon reflexes, also the responsiveness regarding control of heart rhythm by baroreceptors is significantly increased. This finding provides evidence for the impact of a neurological disorder onto the cardiovascular system and its autonomic control.

Published Online: 2018-09-22
Published in Print: 2018-09-01

© 2018 the author(s), published by Walter de Gruyter Berlin/Boston

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

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