Skip to content
BY 4.0 license Open Access Published by De Gruyter November 26, 2020

Development of a biodegradable microstent for minimally invasive treatment of Fallopian tube occlusions

  • Ariane Dierke EMAIL logo , Finja Borowski , Swen Großmann , Christoph Brandt-Wunderlich , Claudia Matschegewski , Paula Rosam , Michael Stiehm , Andrea Bock , Klaus-Peter Schmitz , Stefan Siewert , Nico Pilz , Paul Reister , Kerstin Schümann , Niels Grabow , Klaus-Peter Schmitz , Rebekka Einenkel , Marek Zygmunt , Ulf Hinze , Boris Chichkov , Jonas Keiler and Andreas Wree

Abstract

Obstructions of the Fallopian tube represent one of the most common reasons for an unfulfilled desire to have children. Microstent technology opens up new therapeutic possibilities to restore the natural lumen of the Fallopian tube within a single treatment. Within the current work we developed a self-expandable biodegradable microstent for gynecological applications. Based on a novel microstent design, prototypes were manufactured from poly-L-lactide tubing by means of fs-laser cutting. Microstent prototypes were characterized morphologically by means of scanning electron microscopy and biaxial laser scanning. As manufactured, a microstents outside diameter of about 2.3 mm and a strut thickness / width of about 114 μm / 103 μm was measured. Mechanical characterization of microstents included bending as well as crimping and release behavior. After crimping to a minimum diameter of 0.8 mm and consecutive release, a microstent recovery to a diameter of 1.8 mm was found. Therefore, proof-of-concept for the self-expandable microstent could be successfully provided.

Published Online: 2020-11-26
Published in Print: 2020-09-01

© 2020 by Walter de Gruyter Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

Downloaded on 1.3.2024 from https://www.degruyter.com/document/doi/10.1515/cdbme-2020-3019/html
Scroll to top button