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BY 4.0 license Open Access Published by De Gruyter October 9, 2021

Protein Adsorbate Biohybrids and Sequential Hystallosteric Protein Adsorption

  • Herbert P. Jennissen

Abstract

Protein adsorption on solid surfaces is characterized by multivalence, binding-unit overlap, sequential adsorption, surface allosterics, lateral interactions and pronounced adsorption-desorption hysteresis, giving rise to the sequential, hystallosteric, adsorption model ("SHA model"). Adsorption isotherms of fibrinogen on a titanium miniplates and of the growth factors rhBMP-2 and rhVEGF165 on PDLLA nanofiber fleeces are presented. Controversial Langmuir type isotherms of fibrinogen and rhVEGF165 can be understood on the basis of singular long-lived metastable states central to the SHA-model.

Published Online: 2021-10-09
Published in Print: 2021-10-01

© 2021 The Author(s), published by Walter de Gruyter GmbH, Berlin/Boston

This work is licensed under the Creative Commons Attribution 4.0 International License.

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