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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access November 17, 2014

Plasma-chemical modifications of cellulose for biomedical applications

David Pavliňák, Veronika Švachová, Libor Vojtek, Jana Zarzycká, Pavel Hyršl, Milan Alberti and Lucy Vojtová
From the journal Open Chemistry


A 6-carboxycellulose (in medicine known as “oxidized cellulose” or “oxycellulose”) is one of the cellulose derivatives popular in the field of surgery. Health products based on oxidized cellulose are great local hemostatics with unique bactericidal and fully bioabsorbable effects. Traditional process of native cellulose oxidation is described as a complex radical reaction in strong acidic liquid medium doped by toxic nitrous radicals (NO*). Our plasma-chemical reaction demonstrates a new synthesis method of oxidized cellulose with unique bactericidal effect. This plasma-chemical treatment is based on atmospheric plasma discharge in liquid medium leading to the oxidation of polysaccharide molecules resulting in oxycellulose. Final oxycellulose properties were evaluated by infrared spectroscopy and carboxyl content determination. The biological impact showed a strong germicidal effect.

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[1] Schonauer C., Tessitore E., Barbagallo G., Albanese V., Moraci A., Eur. Spine J., 13, Suppl. 2004, 10, S89 10.1007/s00586-004-0727-zSearch in Google Scholar

[2] Pendharkar S.M., Wissing W.W., European Patent Application EP1424087 A1, 2004.06.02 Search in Google Scholar

[3] Švachová V., Master’s thesis, Masaryk University, Brno, 2012 Search in Google Scholar

[4] Kumar V., Yang T., Carbohyd Polym., 2002, 48, 403 10.1016/S0144-8617(01)00290-9Search in Google Scholar

[5] Bajerova M., Krejcova K., Rabiskova M., Gajdziok J., Masteikova R., Adv. Polym. Tech., 2009, 28, 199 Search in Google Scholar

[6] Yackel E.C., Kenyon W.O., J. Am. Chem Soc., 1942, 64, 121 10.1021/ja01253a032Search in Google Scholar

[7] Friedman A., Plasma Chemistry, Cambridge University Press, USA, 2008 Search in Google Scholar

[8] Atosuo J., Lehtinen J., Vojtek L., Liliu E.M.s, Luminescence, 2013, 28, 771 10.1002/bio.2435Search in Google Scholar PubMed

[9] Buchtikova S., Vetesnikova Simkova A., Rohlenova K., Flajshans M., Lojek A., Lilius E.M., Hyrsl P., Aquaculture, 2011, 318, 169 10.1016/j.aquaculture.2011.05.013Search in Google Scholar

[10] Janča J., Klı́ma M., Slavı́ček P., Zajı́čková L., Surf. Coat. Tech., 1999, 116 Search in Google Scholar

[11] Janča J., Zajíčková L., Klíma M., Slavíček P., Plasma Chem. Plasma P, 2001, 21(4), 565 10.1023/A:1012051102101Search in Google Scholar

[12] United States Pharmacopeia (USP31)–NF26, p. 1702 Search in Google Scholar

[13] Wei L., Bingjie S., Peiyi W., Carbohyd. Polym., 2009, 78, 454 Search in Google Scholar

Received: 2014-1-31
Accepted: 2014-5-29
Published Online: 2014-11-17

© 2015 David Pavliňák et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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