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BY-NC-ND 3.0 license Open Access Published by De Gruyter Open Access October 21, 2015

Development and validation of the simple and sensitive spectrophotometric method of sulphanilamides determination with 4-(2-thiazolylazo)-resorcinol in veterinary preparations

Maria Smolinska , Olha Korkuna , Teodoziya Vrublevska , Petro Rudchuk and Grigory Teslyar
From the journal Open Chemistry

Abstract

New simple, rapid, and accurate spectrophotometric techniques for sulphanilamides assay in combination drugs have been elaborated. The method is based on the formation of coloured products of sulphanilamides diazonium salt azoсoupling with heterocyclic azo reagent 4-(2-thiazolylazo)-resorcinol (TAR) in alkaline medium (pH 9.5) with the following measurement of their absorbance at λmax = 615 nm. Formed products are stable for 1 hour at room temperature. Effective molar absorptivities at absorbance maximum 615 nm for disazo dyes were ~ 104 M-1 cm-1. Linear ranges for sulphanilamides determination were 0.5−30.0 μg mL-1. The developed method was used for the suphanilamides determination in tablets, powder, solutions, suspensions and ointments.

Graphical Abstract

References

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Received: 2014-9-22
Accepted: 2015-4-2
Published Online: 2015-10-21

© 2015 Maria Smolinska et al.

This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License.

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