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Licensed Unlicensed Requires Authentication Published by De Gruyter May 15, 2015

Synthesis of a sialic acid derivative of ristocetin aglycone as an inhibitor of influenza virus

  • Ilona Bakai-Bereczki EMAIL logo , Mihály Herczeg , Bernadett György , Lieve Naesens and Pál Herczegh
From the journal Chemical Papers


In order to promote attachment of the ristocetin aglycone molecule to the surface of the influenza virus, the aglycone was derivatized with a hemagglutinin ligand sialic acid moiety using a click reaction. The sialoristocetin derivative exhibited somewhat lower anti-influenza virus activity than ristocetin and aglycoristocetin.


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Received: 2014-9-30
Revised: 2015-2-18
Accepted: 2015-2-18
Published Online: 2015-5-15
Published in Print: 2015-8-1

© Institute of Chemistry, Slovak Academy of Sciences

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