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Publicly Available Published by De Gruyter March 18, 2015

Otto Wichterle: An Eye for Hydrogels

Daniel Rabinovich
From the journal Chemistry International

Soft contact lenses, worn these days by an estimated 125 million people worldwide, were invented in the early 1960s by Otto Wichterle (1913-1998), an ingenious Czech organic chemist. It was in the mid-1950s that he first prepared poly(2-hydroxyethyl methacrylate), a novel polymeric material that was transparent, absorbed up to 40% of its weight in water to form a colloidal gel, and exhibited suitable mechanical properties for further processing. In a seminal paper published in the 9 January 1960 issue of Nature, Wichterle and Drahoslav Lím, one of his colleagues at the Institute of Macromolecular Chemistry in Prague, outlined the syntheses and properties of hydrophilic gels based on pHEMA and disclosed their potential use in the fabrication of soft contact lenses and other highly biocompatible products. The polymers used to manufacture soft contact lenses were continuously refined in the ensuing decades, particularly to improve oxygen permeability and comfort. The world market value of contact lenses (80% of which are of the soft variety) is now nearly US$8 billion. Significantly, the development of new hydrogels as drug delivery agents, cell culture platforms, artificial cartilage, and other applications in the healthcare industry has been a very active area of research in chemistry and biomedical engineering in recent years.

The Czech stamp illustrated here was issued in 2013 to commemorate the centennial of Wichterle’s birth. In addition to his pioneering work on hydrogels, he studied the polymerization of ε-caprolactam to produce Nylon 6 and investigated the conversion of vinylic halides such as 1,3-dichloro-2-butene to ketones (a variation of the Robinson annulation that now bears his name). He published more than 150 scientific articles and obtained approximately 180 patents for his multiple contributions to chemistry and materials science. In 1967, he became the founder and first president of IUPAC’s Macromolecular Division, which became the Polymer Division (“Division IV”) in 2004. Shortly after democracy was restored in his homeland at the end of 1989, he was elected President of the Czechoslovak Academy of Sciences, a belated honor for a man who served his country in both the political and scientific arenas. Interestingly, even though Wichterle is universally considered the father of soft contact lenses, he never stopped wearing his own pair of eyeglasses!

Online erschienen: 2015-3-18
Erschienen im Druck: 2015-3-1

©2015 by Walter de Gruyter Berlin/Boston

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