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Publicly Available Published by De Gruyter March 7, 2017

Successful Drug Discovery

From the journal Chemistry International

János Fischer and Wayne E. Childers (Eds)

Wiley-VCH, 2016, ISBN: 978-3-527-34115-3

The goal of this book series is to help experts in drug research and development, both in academia and industry, with case histories described by their key inventors or by recognized experts whose contributions can also serve as teaching examples.

Published in December 2016, Volume 2 retains the successful approach found in the previous volume: inventors and primary developers of drugs that made it to market tell the story of the drug’s discovery and development and relate the often twisted route from the first candidate molecule to the final marketed drug. Eleven selected case studies describe recently introduced drugs that have not been previously covered in textbooks or general references. These range across six different therapeutic fields and provide a representative cross-section of current drug development efforts. Sections include:

I. HDAC Inhibitor Anticancer Drug Discovery

II. Steroidal CYP17 Inhibitor Anticancer Drug Discovery

III. Anti-infective Drug Discoveries

IV. Central nervous system (CNS) Drug Discovery

V. Antiulcer Drug Discovery

VI. Cross Therapeutic Drug Discovery (Respiratory Diseases/Anticancer)

2016 marked the 10th anniversary of the approval of vorinostat, the first marketed histone deacetylase (HDCA) inhibitor. This event inaugurated a stream of HDAC inhibitor approvals and confirmed the validity of this drug target and of epigenetic modulation as a viable therapeutic mechanism. To celebrate this important milestone, Successful Drug Discovery presents a number of HDAC inhibitor drug discovery stories.

Backed by copious data and chemical information, the insight and experience of the contributors makes this volume one of the most useful training manuals that a junior medicinal chemist can hope to find. The book is the outcome of an IUPAC project.

See detailed Table of Contents on

Online erschienen: 2017-3-7
Erschienen im Druck: 2017-1-1

©2017 by Walter de Gruyter Berlin/Boston

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