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Licensed Unlicensed Requires Authentication Published by De Gruyter December 12, 2019

Concentration Enrichment of Fermentation Derived Acetic Acid: Transport Modeling of Forward Osmosis-Nanofiltration Integrated System

Jayato Nayak, Parimal Pal, Zunipa Roy, Sankha Chakrabortty, Pinaki Dey, Siddhartha Pandey, S. Anand Kumar Varma and K. Subashini


Forward Osmosis (FO)-Nanofiltration (NF) integration as the final product polishing step enables high concentration of acetic acid output through continuous dehydration of fermentation derived product. A mathematical transport model has been developed based on external and internal concentration polarization modulus of FO and extended Nernst–Plank equation for NF to capture the flux and rejection trends from those membranes. The modular designed production scheme ensured high flux (45 Lm−2 h−1), concentration (962 g L−1) and purity (>98 %) of acetic acid under non-neutralization condition. Excellent performance of the model is reflected in low relative error (<0.05), high Willmott d-index (>0.97) and high correlation coefficient (>0.98).

Funding source: Department of Science and Technology

Award Identifier / Grant number: DST-FIST

Funding statement: Department of Science and Technology, Ministry of Science and Technology, Funder Id:, Grant Number: DST-FIST


The authors acknowledge financial support under DST-FIST Program and Ministry of Human Resource Development of the Government of India.


[1] Nayak J, Pal P. Transforming waste cheese–whey into acetic acid through a continuous membrane-integrated hybrid process. Ind Eng Chem Res. 2013;52:2977–84.10.1021/ie3033729Search in Google Scholar

[2] Law JY, Mohammad AW, Tee ZK, Zaman NK, Jahim J, Santanaraj J, et al. Recovery of succinic acid from fermentation broth by forward osmosis-assisted crystallization process. J Membr Sci. 2019;583:139–51.10.1016/j.memsci.2019.04.036Search in Google Scholar

[3] Nayak J, Pal M, Pal P. Modeling and simulation of direct production of acetic acid from cheese whey in a multi-stage membrane-integrated bioreactor. Biochem Eng J. 2015;93:179–95.10.1016/j.bej.2014.10.002Search in Google Scholar

[4] Pal P, Nayak J. Development and analysis of a sustainable technology in manufacturing acetic acid and whey protein from waste cheese whey. J Cleaner Prod. 2016;112:59–70.10.1016/j.jclepro.2015.07.085Search in Google Scholar

[5] Phuntsho S, Sahebi S, Majeed T, Lotfi F, Kim JE, Shon HK. Assessing the major factors affecting the performances of forward osmosis and its implications on the desalination process. Chem Eng J. 2013;231:484–96.10.1016/j.cej.2013.07.058Search in Google Scholar

[6] Senta I, Mato M, Jakopovic HK, Terzica S, Urkob J, Mijatovi I, et al. Removal of antimicrobials using advanced wastewater treatment. J Hazard Mater. 2011;192:319–28.10.1016/j.jhazmat.2011.05.021Search in Google Scholar

[7] Hancock NT, Cath TY. Solute coupled diffusion in osmotically driven membrane processes. Env Sci Tech. 2009;43:6769–75.10.1021/es901132xSearch in Google Scholar

Received: 2019-02-13
Revised: 2019-10-22
Accepted: 2019-11-26
Published Online: 2019-12-12

© 2019 Walter de Gruyter GmbH, Berlin/Boston