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Licensed Unlicensed Requires Authentication Published by De Gruyter March 1, 2021

A case of newly diagnosed autoimmune diabetes in pregnancy presenting after acute onset of diabetic ketoacidosis

Charissa DiNobile ORCID logo, Anna Fuchs and Kimberly Herrera



We present a case of immune-mediated diabetes mellitus, diagnosed in pregnancy upon presentation with diabetic ketoacidosis, found to have normal glucose control postpartum.

Case presentation

A 28-year-old medically uncomplicated G1P0 presented in diabetic ketoacidosis at 28.2 weeks gestation. Workup for pancreatic autoantibodies revealed indeterminate anti-islet cell antibodies and positive anti-glutamic acid antibodies. She was stabilized with intravenous fluids and insulin, and transitioned to long and short acting subcutaneous insulin. Her insulin requirements decreased over the course of her pregnancy. Spontaneous vaginal delivery occurred at 37 weeks. Her postpartum glucose control was normal without re-initiation of insulin.


The diagnosis of diabetic ketoacidosis during pregnancy should prompt further investigation into an underlying diagnosis of immune mediated diabetes. These patients should be followed closely in the postpartum period.

Corresponding author: Charissa DiNobile, MD, Department of Obstetrics & Gynecology and Reproductive Medicine, Renaissance School of Medicine, Stony Brook University, HSC T-9 Room 030, 101 Nicolls Road, Stony Brook, NY11794, USA, Phone: 641-444-7650, Fax: 631-444-3944, E-mail:

  1. Research funding: None declared.

  2. Author contributions: All authors have accepted responsibility for the entire content of this manuscript and approved its submission.

  3. Competing interests: Authors state no conflict of interest.

  4. Informed consent: Informed consent was obtained from all individuals included in this study.

  5. Ethical approval: Not applicable.


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Received: 2020-05-27
Accepted: 2021-02-08
Published Online: 2021-03-01

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